Antirheumatic Agents:  Novel Methotrexate Derivatives Bearing a Benzoxazine or Benzothiazine Moiety

Hiroharu Matsuoka, N. OHI, Masahiko Mihara, +8

Journal of Medicinal Chemistry

Novel antiasthmatic agents with dual activities of thromboxane A2 synthetase inhibition and bronchodilation. 1. 2-[2-(1-Imidazolyl)alkyl]-1(2H)-phthalazinones

M. YAMAGUCHI, Kenshi Kamei, Takaki Koga, +3

Journal of Medicinal Chemistry

Molecular PharmacologyMedicinal ChemistryPhthalazinone 18BBiochemistryVivo Activities +13

Novel Calcium Antagonists with Both Calcium Overload Inhibition and Antioxidant Activity. 2. Structure−Activity Relationships of Thiazolidinone Derivatives

Tatsuya Kato, Tomokazu Ozaki, Kazuhiko Tamura, +3

Journal of Medicinal Chemistry

Pharmaceutical ScienceHydrogen FumaratePharmacotherapyHeterocycle ChemistryPharmaceutical Chemistry +14

Semisynthetic .BETA.-lactam antibiotics. I. Synthesis and antibacterial activity of new ureidopenicillin derivatives having catechol moieties.

N. OHI, Bunya Aoki, TEIZO SHINOZAKI, +5

The Journal of Antibiotics

Improved synthetic methods of CP-060S, a novel cardioprotective drug

Tatsuya Kato, Tomokazu Ozaki, N. OHI

Tetrahedron Asymmetry

Synthetic MethodsMedicineCardiovascular PharmacologyPharmacotherapyDrug Development +2

Novel Calcium Antagonists with Both Calcium Overload Inhibition and Antioxidant Activity. 1. 2-(3,5-Di-<i>tert-</i>butyl-4-hydroxyphenyl)-3-(aminopropyl)thiazolidinones

Tatsuya Kato, Tomokazu Ozaki, Kazuhiko Tamura, +3

Journal of Medicinal Chemistry

Novel antiasthmatic agents with dual activities of thromboxane A2 synthetase inhibition and bronchodilation. 2. 4-(3-Pyridyl)-1(2H)-phthalazinones

M. YAMAGUCHI, Kenshi Kamei, Takaki Koga, +4

Journal of Medicinal Chemistry

Combinatorial ChemistryMedicinal ChemistryHeterocyclicBiochemistryMedicine +12

Semisynthetic .BETA.-lactam antibiotics. IV. Synthesis and antibacterial activity of new ureidocephalosporin and ureidocephamycin derivatives containing a catechol moiety or its acetate.

N. OHI, Bunya Aoki, TEIZO SHINOZAKI, +7

Chemical and Pharmaceutical Bulletin

Bioorganic ChemistryAntibacterial ActivityAntimicrobial ChemotherapyBacterial PathogensPharmaceutical Chemistry +25

Semisynthetic .BETA.-lactam antibiotics. II. Effect on antibacterial activity of ureido N-substituents in the 6-((R)-2-(3-(3,4-dihydroxybenzoyl)-1-ureido)-2-phenylacetamido)penicillanic acids.

N. OHI, Bunya Aoki, KANZI MORO, +7

The Journal of Antibiotics

Practical Synthesis of Novel Cardioprotective Drug, CP-060<i>S</i>

Tatsuya Kato, Tomokazu Ozaki, Kouichi Tsuzuki, +1

Organic Process Research & Development

Chiral AcidEnantioselective SynthesisEngineeringAlcohol IntermediateMedicine +12