The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

Laurent Mouchiroud, Riekelt H. Houtkooper, Norman Moullan, +9

Cell

Lifespan ExtensionReductive StressAnti-agingAgingMitochondrial Function +9

Mitonuclear protein imbalance as a conserved longevity mechanism

Riekelt H. Houtkooper, Laurent Mouchiroud, Dongryeol Ryu, +5

Nature

Lifespan ExtensionAgingLongevityGeneticsCellular Senescence +4

Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents

Dongryeol Ryu, Laurent Mouchiroud, Pénélope A. Andreux, +11

Nature Medicine

BiologyLifespan ExtensionMitophagyA Induces MitophagyPhysiology +8

Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity

Vincenzo Sorrentino, Mario Romani, Laurent Mouchiroud, +9

Nature

Mitochondrial FunctionBiochemistryMedicineNatural SciencesMitochondrial Dynamic +4

Tetracyclines Disturb Mitochondrial Function across Eukaryotic Models: A Call for Caution in Biomedical Research

Norman Moullan, Laurent Mouchiroud, Xu Wang, +9

Cell Reports

Eliciting the mitochondrial unfolded protein response by nicotinamide adenine dinucleotide repletion reverses fatty liver disease in mice

Karim Gariani, Keir J. Menzies, Dongryeol Ryu, +20

Hepatology

Pharmacological Inhibition of Poly(ADP-Ribose) Polymerases Improves Fitness and Mitochondrial Function in Skeletal Muscle

Eija Pirinen, Carles Cantó, Young Suk Jo, +19

Cell Metabolism

Muscle FunctionMuscle InjuryMitochondrial FunctionBiochemistryMitochondrial Biogenesis +7

A TP53 polymorphism is associated with increased risk of colorectal cancer and with reduced levels of TP53 mRNA

Federica Gemignani, Vı́ctor Moreno, Stefano Landi, +8

Oncogene

Tumor BiologyCancer RiskMedicineGeneticsGenetic Epidemiology +8

ATM haplotypes and cellular response to DNA damage: association with breast cancer risk and clinical radiosensitivity.

Sandra Angèle, P. Romestaing, Norman Moullan, +8

PubMed

Dna DamageGeneticsRadiation EffectGenetic EpidemiologyHuman Polymorphism +17

Super‐Resolution Biological Microscopy Using Virtual Imaging by a Microsphere Nanoscope

Hui Yang, Norman Moullan, Johan Auwerx, +1

Small

EngineeringMicroscopyBiomedical EngineeringSuper-resolution MicroscopySuper-resolution Imaging +15