Design and synthesis of a highly selective, orally active and potent anaplastic lymphoma kinase inhibitor (CH5424802)

Kazutomo Kinoshita, Kohsuke Asoh, Noriyuki Furuichi, +11

Bioorganic & Medicinal Chemistry

Chemoprevention StrategyMedicineAnti-cancer AgentPharmacologyRadiation Oncology +1

Development of Orally Bioavailable Peptides Targeting an Intracellular Protein: From a Hit to a Clinical KRAS Inhibitor

Mikimasa Tanada, Minoru Tamiya, Atsushi Matsuo, +22

Journal of the American Chemical Society

Malignant Tumors in Choledochal Cysts

Ryoichi Tsuchiya, Noboru Harada, Toshiya Ito, +4

Annals of Surgery

Validation of a New Methodology to Create Oral Drugs beyond the Rule of 5 for Intracellular Tough Targets

Atsushi Ohta, Mikimasa Tanada, Shojiro Shinohara, +44

Journal of the American Chemical Society

9-Substituted 6,6-Dimethyl-11-oxo-6,11-dihydro-5<i>H</i>-benzo[<i>b</i>]carbazoles as Highly Selective and Potent Anaplastic Lymphoma Kinase Inhibitors

Kazutomo Kinoshita, Takamitsu Kobayashi, Kohsuke Asoh, +14

Journal of Medicinal Chemistry

Compound 13DMolecular PharmacologyMedicinal ChemistryHigh Target SelectivityMedicine +10

Discovery of novel tetracyclic compounds as anaplastic lymphoma kinase inhibitors

Kazutomo Kinoshita, Yoshiyuki Ono, Takashi Emura, +10

Bioorganic & Medicinal Chemistry Letters

MedicineNovel Tetracyclic CompoundsAnti-cancer AgentDrug DevelopmentPharmacology +2

Preparation of polyamine antibody and its use in enzyme immunoassay of spermine and spermidine with β-D-galactosidase as a label

Kunio Fujiwara, Hisatsugu Asada, Tsunehiro Kitagawa, +9

Journal of Immunological Methods

SpermatogenesisInfertilityEnzyme ImmunoassayAllergyPolyamine Antibody +6

Penetration of Oral Fluconazole into Gynecological Tissues

Hiroshige Mikamo, Kyoko Kawazoe, Yasumasa Sato, +4

Antimicrobial Agents and Chemotherapy

Hyperbaric oxygen therapy in the treatment of refractory peripancreatic abscess associated with severe acute pancreatitis

Kunihide Izawa, Tsukasa Tsunoda, Kazuhide Ura, +4

Gastroenterologia Japonica

Severe Acute PancreatitisPancreatic Fluid CollectionGastroenterologyPancreatic SurgeryHyperbaric Oxygen Therapy +3

SARCOMA BOTRYOIDES ARISING FROM THE BILIARY TRACT OF CHILDREN — A CASE REPORT WITH REVIEW OF THE LITERATURE

Yoshitsugi Taira, Iwao Nakayama, Akira Moriuchi, +5

Acta Pathologica Japonica