Defective proviruses rapidly accumulate during acute HIV-1 infection

Katherine M. Bruner, Alexandra J. Murray, Ross A. Pollack, +12

Nature Medicine

Defective ProvirusesViral PersistenceHuman RetrovirusImmunologyVirology +4

A quantitative approach for measuring the reservoir of latent HIV-1 proviruses

Katherine M. Bruner, Zheng Wang, Francesco R. Simonetti, +23

Nature

Viral PersistenceViral DiagnosticsHuman RetrovirusImmunologyQuantitative Approach +6

Proliferation of latently infected CD4+ T cells carrying replication-competent HIV-1: Potential role in latent reservoir dynamics

Nina N. Hosmane, Kyungyoon J. Kwon, Katherine M. Bruner, +7

The Journal of Experimental Medicine

Defective HIV-1 Proviruses Are Expressed and Can Be Recognized by Cytotoxic T Lymphocytes, which Shape the Proviral Landscape

Ross A. Pollack, R. Brad Jones, Mihaela Pertea, +14

Cell Host & Microbe

Primary ImmunodeficiencyProviral LandscapeCytotoxic T LymphocytesViral ReplicationHuman Retrovirus +8

Expanded cellular clones carrying replication-competent HIV-1 persist, wax, and wane

Zheng Wang, Evelyn Gurule, Timothy Brennan, +11

Proceedings of the National Academy of Sciences

Viral ReplicationImmunologyViral DynamicMolecular BiologyReplication-competent Hiv-1 Persist +14

Transcriptional Reprogramming during Effector-to-Memory Transition Renders CD4+ T Cells Permissive for Latent HIV-1 Infection

Liang Shan, Kai Deng, Hongbo Gao, +16

Immunity

Latent Hiv-1 InfectionHuman RetrovirusImmunologyAntiviral ResponseHiv +4

Combined HIV-1 sequence and integration site analysis informs viral dynamics and allows reconstruction of replicating viral ancestors

Sean C. Patro, Leah D. Brandt, Michael J. Bale, +27

Proceedings of the National Academy of Sciences

Impact of Myc in HIV-associated non-Hodgkin lymphomas treated with EPOCH and outcomes with vorinostat (AMC-075 trial)

Juan Carlos Ramos, Joseph A. Sparano, Amy Chadburn, +15

Blood

Rapamycin-mediated mTOR inhibition uncouples HIV-1 latency reversal from cytokine-associated toxicity

Alyssa R. Martin, Ross A. Pollack, Adam A. Capoferri, +3

Journal of Clinical Investigation

Rapamycin TreatmentImmunodeficienciesImmunologyImmune RegulationImmunodominance +20

HIV Infected T Cells Can Proliferate in vivo Without Inducing Expression of the Integrated Provirus

Andrew Musick, Jonathan Spindler, Eli Boritz, +16

Frontiers in Microbiology