J. Fernando Dı́az

A new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs

A.E. Prota, Katja Bargsten, J. Fernando Dı́az et al. · Proceedings of the National Academy of Sciences · 2014 · 279 citations · Full text

Life Sciences, Medicinal Chemistry, Oncology +17

The Microtubule Stabilizing Agent Laulimalide Does Not Bind in the Taxoid Site, Kills Cells Resistant to Paclitaxel and Epothilones, and May Not Require Its Epoxide Moiety for Activity

Donald E. Pryor, Aurora O’Brate, Geoffrey Bilcer et al. · Biochemistry · 2002 · 255 citations

Medicine, Oncology, Pharmacology +17

Insights into the Distinct Mechanisms of Action of Taxane and Non-Taxane Microtubule Stabilizers from Cryo-EM Structures

Elizabeth H. Kellogg, Nisreen M.A. Hejab, Stuart C. Howes et al. · Journal of Molecular Biology · 2017 · 241 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +15

Microtubule Interactions with Chemically Diverse Stabilizing Agents: Thermodynamics of Binding to the Paclitaxel Site Predicts Cytotoxicity

Rubén M. Buey, Isabel Barasoaı́n, Evelyn M. Jackson et al. · Chemistry & Biology · 2005 · 227 citations · Full text

Medicine, Oncology, Pharmacology +16

Peloruside A Does Not Bind to the Taxoid Site on β-Tubulin and Retains Its Activity in Multidrug-Resistant Cell Lines

Thomas N. Gaitanos, Rubén M. Buey, J. Fernando Dı́az et al. · Cancer Research · 2004 · 193 citations

Life Sciences, Biochemistry, Molecular Biology +17