Identification of NVP-BKM120 as a Potent, Selective, Orally Bioavailable Class I PI3 Kinase Inhibitor for Treating Cancer

Matthew T. Burger, Sabina Pecchi, Allan S. Wagman, +27

ACS Medicinal Chemistry Letters

2,4-Bismorpholino 6-Heterocyclic PyrimidinesPi3 Kinase InhibitorOrally Bioavailable ClassGliomaPharmaceutical Chemistry +16

Rationally Designed PI3Kα Mutants to Mimic ATR and Their Use to Understand Binding Specificity of ATR Inhibitors

Yipin Lu, Mark Knapp, Kenneth Crawford, +16

Journal of Molecular Biology

Molecular PharmacologyPikk FamilyProtein FunctionSignal TransductionBiochemistry +13

Baculovirus-driven protein expression in insect cells: A benchmarking study

Peggy Stolt-Bergner, Christian Benda, Tim Bergbrede, +24

Journal of Structural Biology

Molecular VirologyInsect VirusInsect CellsPathogenesisImmunology +3

Abstract 4498: Biological characterization of NVP-BKM120, a novel inhibitor of phosphoinosotide 3-kinase in Phase I/II clinical trials

Charles F. Voliva, Sabina Pecchi, Matthew T. Burger, +14

Cancer Research

Novel InhibitorPi3k InhibitorsAdditional Pi3k InhibitorsTumor BiologyPre-clinical Pharmacology +23

Inhibition of prenylated KRAS in a lipid environment

Johanna M. Jansen, Charles Wartchow, Wolfgang Jahnke, +33

PLoS ONE

Signal TransductionBiochemistryKras InhibitionRas MutationsNatural Sciences +11

Subset of Hybrid Eukaryotic Proteins Is Exported by the Type I Secretion System of <i>Erwinia chrysanthemi</i>

José Luis Palacios, Isabel Zaror, Patricio Martı́nez, +5

Journal of Bacteriology

Structural basis for therapeutic inhibition of influenza A polymerase PB2 subunit

Xiaolei Ma, Lili Xie, Charles Wartchow, +12

Scientific Reports

Fructose‐1,6‐bisphosphatase of the yeast <i>Kluyveromyces lactis</i>

Isabel Zaror, Donna L. Moyer, James Tung, +1

European Journal of Biochemistry

The nucleotide sequence of the<i>Salmonella typhi</i>ompC porin gene

Alejandro Venegas, Isabel Gómez, Isabel Zaror, +1

Nucleic Acids Research

Pathogen DetectionMicrobial PathogensMolecular EpidemiologyGeneticsMolecular Biology +15

High-level soluble expression, purification and characterization of active human midkine from Escherichia coli

Marjo Goette, Gabriele Hofmann, Isabel Zaror, +1

Protein Expression and Purification

Protein ExpressionHigh-level Soluble ExpressionBioanalysisImmunologyBiotechnology +6