Involvement of an increased spinal TRPV1 sensitization through its up-regulation in mechanical allodynia of CCI rats

Yoshihito Kanai, Etsuko Nakazato, Akiyoshi Fujiuchi, +2

Neuropharmacology

Mechanical AllodyniaCci RatsNeuroanatomyPhysiologyImmunology +7

Antiinflammatory and analgesic activity of a non-peptide substance P receptor antagonist

Atsushi Nagahisa, Yoshihito Kanai, Osamu Suga, +4

European Journal of Pharmacology

Anti-inflammatoryHealth SciencesPain MedicinePharmacologyPharmacological Agent +7

Differential involvement of TRPV1 receptors at the central and peripheral nerves in CFA-induced mechanical and thermal hyperalgesia

Yoshihito Kanai, Tomokazu Hara, Aki Imai, +1

Journal of Pharmacy and Pharmacology

Discovery and stereoselective synthesis of the novel isochroman neurokinin-1 receptor antagonist ‘CJ-17,493’

Yuji Shishido, H. Wakabayashi, Hiroki Koike, +15

Bioorganic & Medicinal Chemistry

Molecular PharmacologyMedicinal ChemistryBiochemistryMedicineNatural Sciences +7

Non‐specific activity of (±)‐CP‐96,345 in models of pain and inflammation

Atsushi Nagahisa, Rinko Asai, Yoshihito Kanai, +5

British Journal of Pharmacology

Nk1 Receptor AntagonistPain DisordersEnantiomer Cp-96,344Acute PainPain Medicine +19

Participation of the spinal TRPV1 receptors in formalin-evoked pain transduction: a study using a selective TRPV1 antagonist, iodo-resiniferatoxin

Yoshihito Kanai, Tomokazu Hara, Aki Imai

Journal of Pharmacy and Pharmacology

Anti-Emetic Activity of the Novel Nonpeptide Tachykinin NK<sub>1</sub> Receptor Antagonist Ezlopitant (CJ-11,974) against Acute and Delayed Cisplatin-Induced Emesis in the Ferret

Megumi Tsuchiya, Y. Fujiwara, Yoshihito Kanai, +6

Pharmacology

Selective NkImmunologyReceptor AntagonistPharmacotherapyExperimental Pharmacology +15

Synthesis of benzamide derivatives as TRPV1 antagonists

Yuji Shishido, Madoka Jinno, Takafumi Ikeda, +9

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyMedicinal ChemistryDerivative (Chemistry)DerivativesBenzamide Derivatives +4

Studies on Somnolence in the Daytime Caused by Drugs Used for Neuropathic Pain

Yasuhiro Takeda, Takayuki Ishida, Ryuki Tsutsui, +5

Journal of Pharmacological Sciences

Pharmacological separation between peripheral and central functions of cyclooxygenase-2 with CIAA, a novel cyclooxygenase-2 inhibitor

Takako Okumura, Yoko Murata, Masanori Hizue, +7

European Journal of Pharmacology

BiochemistryMedicinePhysiologyMechanism Of ActionPharmacological Agent +7