Tobias Claff

Elucidating the active δ-opioid receptor crystal structure with peptide and small-molecule agonists

Tobias Claff, Jing Yu, Véronique Blais et al. · Science Advances · 2019 · 126 citations · Full text

Medicine, Chemistry, Pharmacology +16

Discovery and Crystallographic Studies of Trisubstituted Piperazine Derivatives as Non-Covalent SARS-CoV-2 Main Protease Inhibitors with High Target Specificity and Low Toxicity

Shenghua Gao, Katharina Sylvester, Letian Song et al. · Journal of Medicinal Chemistry · 2022 · 83 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Inhibition of cellular RNA methyltransferase abrogates influenza virus capping and replication

Yuta Tsukamoto, Takahiro Hiono, Shintaro Yamada et al. · Science · 2023 · 43 citations

Life Sciences, Microbiology, Molecular Biology +17

Discovery and Crystallographic Studies of Nonpeptidic Piperazine Derivatives as Covalent SARS-CoV-2 Main Protease Inhibitors

Shenghua Gao, Letian Song, Tobias Claff et al. · Journal of Medicinal Chemistry · 2022 · 34 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

Single Stabilizing Point Mutation Enables High‐Resolution Co‐Crystal Structures of the Adenosine A_2A Receptor with Preladenant Conjugates

Tobias Claff, Tim A. Klapschinski, Udaya K. Tiruttani Subhramanyam et al. · Angewandte Chemie International Edition · 2022 · 24 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +12