The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K

Mikołaj Słabicki, Zuzanna Kozicka, Georg Petzold, +21

Nature

Protein FunctionSignal TransductionCell RegulationNatural SciencesCdk Inhibitor Cr8 +8

Small-molecule-induced polymerization triggers degradation of BCL6

Mikołaj Słabicki, Hojong Yoon, Jonas Koeppel, +18

Nature

EngineeringPolymer ScienceMolecular BiologyMacromolecular SystemPolymerization Kinetics +2

Selection of Oncogenic Mutant Clones in Normal Human Skin Varies with Body Site

Joanna C. Fowler, Charlotte King, Chris Bryant, +18

Cancer Discovery

Prediction of prime editing insertion efficiencies using sequence features and DNA repair determinants

Jonas Koeppel, Juliane Weller, Elin Madli Peets, +6

Nature Biotechnology

Degradation of GSPT1 causes TP53-independent cell death in leukemia while sparing normal hematopoietic stem cells

Rob S. Sellar, Adam S. Sperling, Mikołaj Słabicki, +26

Journal of Clinical Investigation

ApoptosisCell DeathCancer BiologyTumor BiologyGspt1 Degradation +16

Loss of Neurological Disease HSAN-I-Associated Gene SPTLC2 Impairs CD8+ T Cell Responses to Infection by Inhibiting T Cell Metabolic Fitness

Jingxia Wu, Sicong Ma, Roger Sandhoff, +24

Immunity

Autoimmune DiseaseMedicineT-regulatory CellImmunologyAutoimmunity +6

Base editing screens define the genetic landscape of cancer drug resistance mechanisms

Matthew A. Coelho, Magdalena E Strauß, Alex Watterson, +20

Nature Genetics

Predicting base editing outcomes using position-specific sequence determinants

Ananth Pallaseni, Elin Madli Peets, Jonas Koeppel, +7

Nucleic Acids Research

Randomizing the human genome by engineering recombination between repeat elements

Jonas Koeppel, Raphaël Ferreira, Thomas Vanderstichele, +9

Science

BTBBCL6 dimers as building blocks for reversible drug-induced protein oligomerization

Lena Nitsch, Patrizia Jensen, Hojong Yoon, +6

Cell Reports Methods