Increased neutrophil extracellular trap formation promotes thrombosis in myeloproliferative neoplasms

Ofir Wolach, Rob S. Sellar, Kimberly Martinod, +21

Science Translational Medicine

The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K

Mikołaj Słabicki, Zuzanna Kozicka, Georg Petzold, +21

Nature

Protein FunctionSignal TransductionCell RegulationNatural SciencesCdk Inhibitor Cr8 +8

PPM1D-truncating mutations confer resistance to chemotherapy and sensitivity to PPM1D inhibition in hematopoietic cells

Josephine Kahn, Peter G. Miller, Alexander J. Silver, +15

Blood

Clonal haematopoiesis and risk of chronic liver disease

Waihay J. Wong, Connor A. Emdin, Alexander G. Bick, +32

Nature

HepatologyLiver PhysiologyImmunologyHematologyHepatitis +8

The importance of relative mutant level for evaluating impact on outcome of KIT, FLT3 and CBL mutations in core-binding factor acute myeloid leukemia

Christopher Allen, Robert K. Hills, Katarina Lamb, +8

Leukemia

Hematological MalignancySystems BiologyOncologyCbl MutationsEngineering +10

Patterns of substrate affinity, competition, and degradation kinetics underlie biological activity of thalidomide analogs

Adam S. Sperling, Michael Burgess, Hasmik Keshishian, +19

Blood

Degradation of GSPT1 causes TP53-independent cell death in leukemia while sparing normal hematopoietic stem cells

Rob S. Sellar, Adam S. Sperling, Mikołaj Słabicki, +26

Journal of Clinical Investigation

ApoptosisCell DeathCancer BiologyTumor BiologyGspt1 Degradation +16

Molecular MRD is strongly prognostic in patients with <i>NPM1</i>-mutated AML receiving venetoclax-based nonintensive therapy

Jad Othman, Ing Soo Tiong, Jenny O’Nions, +32

Blood

Mrd NegativityMixed-phenotype Acute LeukemiaImmunologyPathologyMeasurable Residual Disease +15

PIM and AKT kinase inhibitors show synergistic cytotoxicity in acute myeloid leukaemia that is associated with convergence on <scp>mTOR</scp> and MCL1 pathways

Koremu Meja, Chloe Stengel, Rob S. Sellar, +5

British Journal of Haematology

Avadomide Induces Degradation of ZMYM2 Fusion Oncoproteins in Hematologic Malignancies

Aline Renneville, Jessica A. Gasser, Daniel E. Grinshpun, +19

Blood Cancer Discovery