Josephine Kahn

PPM1D-truncating mutations confer resistance to chemotherapy and sensitivity to PPM1D inhibition in hematopoietic cells

Josephine Kahn, Peter G. Miller, Alexander J. Silver et al. · Blood · 2018 · 213 citations · Full text

SETD2 alterations impair DNA damage recognition and lead to resistance to chemotherapy in leukemia

Brenton G. Mar, S. Haihua Chu, Josephine Kahn et al. · Blood · 2017 · 145 citations · Full text

PPM1D modulates hematopoietic cell fitness and response to DNA damage and is a therapeutic target in myeloid malignancy

Peter G. Miller, Adam S. Sperling, Christina Mayerhofer et al. · Blood · 2023 · 35 citations · Full text

Allosteric inhibition of PPM1D serine/threonine phosphatase via an altered conformational state

Peter G. Miller, Murugappan Sathappa, Jamie A. Moroco et al. · Nature Communications · 2022 · 34 citations · Full text