Xanthine Oxidoreductase Is Involved in Macrophage Foam Cell Formation and Atherosclerosis Development

Akifumi Kushiyama, Hirofumi Okubo, Hideyuki Sakoda, +10

Arteriosclerosis Thrombosis and Vascular Biology

<i>Lactobacillus casei</i>strain Shirota protects against nonalcoholic steatohepatitis development in a rodent model

Hirofumi Okubo, Hideyuki Sakoda, Akifumi Kushiyama, +11

American Journal of Physiology-Gastrointestinal and Liver Physiology

NutritionDysbiosisRodent ModelPathologyGut Microbiota +15

Adipocyte-macrophage interaction may mediate LPS-induced low-grade inflammation: Potential link with metabolic complications

Hideo Nakarai, Akiko Yamashita, Shintaro Nagayasu, +9

Innate Immunity

Possible involvement of normalized Pin1 expression level and AMPK activation in the molecular mechanisms underlying renal protective effects of SGLT2 inhibitors in mice

Masa-ki Inoue, Yasuka Matsunaga, Yusuke Nakatsu, +13

Diabetology & Metabolic Syndrome

DPP-IV inhibitor anagliptin exerts anti-inflammatory effects on macrophages, adipocytes, and mouse livers by suppressing NF-κB activation

Takanori Shinjo, Yusuke Nakatsu, Misaki Iwashita, +10

American Journal of Physiology-Endocrinology and Metabolism

Visceral Adipose TissueLung InflammationImmunologyImmune RegulationAnti-inflammatory Effects +19

Extracellular vesicles derived from GMSCs stimulated with TNF-α and IFN-α promote M2 macrophage polarization via enhanced CD73 and CD5L expression

Yukari Watanabe, Takao Fukuda, Chikako Hayashi, +11

Scientific Reports

Protection from diet-induced obesity and insulin resistance in mice lacking CCL19-CCR7 signaling

Tomomi Sano, Misaki Iwashita, Shintaro Nagayasu, +8

Obesity

Prolyl Isomerase Pin1 Negatively Regulates AMP-activated Protein Kinase (AMPK) by Associating with the CBS Domain in the γ Subunit

Yusuke Nakatsu, Misaki Iwashita, Hideyuki Sakoda, +13

Journal of Biological Chemistry

Protein FunctionSignal TransductionMolecular PhysiologyBiochemistrySignaling Pathway +11

Epicatechin downregulates adipose tissue CCL19 expression and thereby ameliorates diet-induced obesity and insulin resistance

Tomomi Sano, Shintaro Nagayasu, Shigeki Suzuki, +8

Nutrition Metabolism and Cardiovascular Diseases

Insulin ResistanceObesityMetabolic SyndromeInsulin SignalingBiochemistry +9

Valsartan, independently of AT1 receptor or PPARγ, suppresses LPS-induced macrophage activation and improves insulin resistance in cocultured adipocytes

Misaki Iwashita, Hideyuki Sakoda, Akifumi Kushiyama, +13

American Journal of Physiology-Endocrinology and Metabolism

ImmunologyMetabolic RemodelingInsulin SignalingInflammationMetabolic Syndrome +19