Brian S. J. Blagg

A first-in-class polymerase theta inhibitor selectively targets homologous-recombination-deficient tumors

Jia Zhou, Camille Gelot, Constantia Pantelidou et al. · Nature Cancer · 2021 · 320 citations · Full text

Molecular Biology, Cancer Genetics, Medicine +3

Novobiocin:  Redesigning a DNA Gyrase Inhibitor for Selective Inhibition of Hsp90

Joseph A. Burlison, Len Neckers, Andrew Smith et al. · Journal of the American Chemical Society · 2006 · 233 citations

Swe1Wee1-Dependent Tyrosine Phosphorylation of Hsp90 Regulates Distinct Facets of Chaperone Function

Mehdi Mollapour, Shinji Tsutsumi, Alison C. Donnelly et al. · Molecular Cell · 2010 · 191 citations · Full text

Protein Function, Signal Transduction, Chaperone Function +11

Hsp90 Inhibitors Identified from a Library of Novobiocin Analogues

Xiao Yu, Gang Shen, Len Neckers et al. · Journal of the American Chemical Society · 2005 · 170 citations

Gedunin, a Novel Hsp90 Inhibitor: Semisynthesis of Derivatives and Preliminary Structure−Activity Relationships

Gary Brandt, Matthew Schmidt, Thomas E. Prisinzano et al. · Journal of Medicinal Chemistry · 2008 · 162 citations · Full text

Molecular Biology, Chemical Biology, Pharmaceutical Chemistry +19