Matthew R. Kaller

Design and Preparation of a Potent Series of Hydroxyethylamine Containing β-Secretase Inhibitors That Demonstrate Robust Reduction of Central β-Amyloid

Matthew M. Weiss, Toni Williamson, Safura Babu‐Khan et al. · Journal of Medicinal Chemistry · 2012 · 64 citations · Full text

Medicine, Pharmacokinetics, Pharmacology +17

Discovery of TRPM8 Antagonist (<i>S</i>)-6-(((3-Fluoro-4-(trifluoromethoxy)phenyl)(3-fluoropyridin-2-yl)methyl)carbamoyl)nicotinic Acid (AMG 333), a Clinical Candidate for the Treatment of Migraine

Daniel B. Horne, Kaustav Biswas, James Brown et al. · Journal of Medicinal Chemistry · 2018 · 61 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +15

Optimization of Potency and Pharmacokinetic Properties of Tetrahydroisoquinoline Transient Receptor Potential Melastatin 8 (TRPM8) Antagonists

Daniel B. Horne, Nuria Tamayo, Michael D. Bartberger et al. · Journal of Medicinal Chemistry · 2014 · 42 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Design and Synthesis of Potent, Orally Efficacious Hydroxyethylamine Derived β-Site Amyloid Precursor Protein Cleaving Enzyme (BACE1) Inhibitors

Thomas A. Dineen, Matthew M. Weiss, Toni Williamson et al. · Journal of Medicinal Chemistry · 2012 · 41 citations · Full text

Pharmacy, Pharmacokinetics, Pharmacology +12

Structure–activity relationships of 3,4-dihydro-1H-quinazolin-2-one derivatives as potential CDK5 inhibitors

Robert M. Rzasa, Matthew R. Kaller, Gang Liu et al. · Bioorganic & Medicinal Chemistry · 2007 · 38 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13