Gut microbiome–derived metabolites modulate intestinal epithelial cell damage and mitigate graft-versus-host disease

Nathan D. Mathewson, Robert R. Jenq, Anna V. Mathew, +18

Nature Immunology

InflammationMicrobiota FunctionGraft-versus-host DiseaseMucosal ImmunologyDysbiosis +8

Siglec-G–CD24 axis controls the severity of graft-versus-host disease in mice

Tomomi Toubai, Guoqing Hou, Nathan D. Mathewson, +12

Blood

Mature T cell responses are controlled by microRNA-142

Yaping Sun, Katherine Oravecz-Wilson, Nathan D. Mathewson, +9

Journal of Clinical Investigation

Lymphocyte DevelopmentAdaptive Immune SystemT-regulatory CellImmunologyImmune System +18

BET bromodomain inhibition suppresses graft-versus-host disease after allogeneic bone marrow transplantation in mice

Yaping Sun, Ying Wang, Tomomi Toubai, +9

Blood

Siglec-G represses DAMP-mediated effects on T cells

Tomomi Toubai, Corinne Rossi, Katherine Oravecz-Wilson, +12

JCI Insight

T-regulatory CellImmunologyImmune RegulationImmunologic MechanismDonor T Cells +14

Host NLRP6 exacerbates graft-versus-host disease independent of gut microbial composition

Tomomi Toubai, Hideaki Fujiwara, Corinne Rossi, +19

Nature Microbiology

Host ResponseDysbiosisHost Nlrp6Mucosal ImmunologyPathogenesis +8

SAG/Rbx2-Dependent Neddylation Regulates T-Cell Responses

Nathan D. Mathewson, Hideaki Fujiwara, Shin-Rong Wu, +7

American Journal Of Pathology

Signal TransductionCell RegulationT-regulatory CellCellular Regulatory MechanismMedicine +3

Mitochondrial Deacetylase SIRT3 Plays an Important Role in Donor T Cell Responses after Experimental Allogeneic Hematopoietic Transplantation

Tomomi Toubai, Hiroya Tamaki, Daniel Peltier, +11

The Journal of Immunology

Murine Models of Steroid Refractory Graft-versus-Host Disease

Tomomi Toubai, Corinne Rossi, Isao Tawara, +11

Scientific Reports

IAPs protect host target tissues from graft-versus-host disease in mice

Tomomi Toubai, Corinne Rossi, Katherine Oravecz-Wilson, +13

Blood Advances