Marilena Margiotta

Mutant p53 prevents GAPDH nuclear translocation in pancreatic cancer cells favoring glycolysis and 2-deoxyglucose sensitivity

Giovanna Butera, Raffaella Pacchiana, Nidula Mullappilly et al. · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · 2018 · 57 citations · Full text

Medicine, Molecular Biology, Oncology +17

Molecular basis for covalent inhibition of glyceraldehyde‐3‐phosphate dehydrogenase by a 2‐phenoxy‐1,4‐naphthoquinone small molecule

Stefano Bruno, Elisa Uliassi, Mirko Zaffagnini et al. · Chemical Biology & Drug Design · 2017 · 22 citations · Full text

Life Sciences, Biochemistry, Medicinal Chemistry +13

Selectivity of 3-bromo-isoxazoline inhibitors between human and Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenases

Stefano Bruno, Marilena Margiotta, Andrea Pinto et al. · Bioorganic & Medicinal Chemistry · 2016 · 21 citations

Pharmacy, Medicinal Chemistry, Pharmacology +13

Magnesium and calcium ions differentially affect human serine racemase activity and modulate its quaternary equilibrium toward a tetrameric form

Stefano Bruno, Marilena Margiotta, Francesco Marchesani et al. · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · 2017 · 21 citations

Life Sciences, Biochemistry, Calcium Homeostasis +9

Covalent Inhibitors of <i>Plasmodium falciparum</i> Glyceraldehyde 3-Phosphate Dehydrogenase with Antimalarial Activity in Vitro

Gregorio Cullia, Stefano Bruno, Silvia Parapini et al. · ACS Medicinal Chemistry Letters · 2019 · 14 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17