Mark Pruzanski

TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis

Charles Thomas, Antimo Gioiello, Lilia G. Noriega et al. · Cell Metabolism · 2009 · 1.8K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +10

A Placebo-Controlled Trial of Obeticholic Acid in Primary Biliary Cholangitis

Frederik Nevens, Pietro Andreoné, G. Mazzella et al. · New England Journal of Medicine · 2016 · 1.1K citations · Full text

Medicine, Pharmacology, Pharmacotherapy +16

Efficacy and Safety of the Farnesoid X Receptor Agonist Obeticholic Acid in Patients With Type 2 Diabetes and Nonalcoholic Fatty Liver Disease

Sunder Mudaliar, Robert R. Henry, Arun J. Sanyal et al. · Gastroenterology · 2013 · 915 citations

Medicine, Endocrinology, Pharmacology +12

Discovery of 6α-Ethyl-23(<i>S</i>)-methylcholic Acid (<i>S</i>-EMCA, INT-777) as a Potent and Selective Agonist for the TGR5 Receptor, a Novel Target for Diabesity

Roberto Pellicciari, Antimo Gioiello, Antonio Macchiarulo et al. · Journal of Medicinal Chemistry · 2009 · 255 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

FXR/TGR5 Dual Agonist Prevents Progression of Nephropathy in Diabetes and Obesity

Xiaoxin X. Wang, Dong Wang, Yuhuan Luo et al. · Journal of the American Society of Nephrology · 2017 · 222 citations · Full text

Medicine, Endocrinology, Pharmacology +14