Timothy J. Blake

The sequences of the human and mouse c-cbl proto-oncogenes show v-cbl was generated by a large truncation encompassing a proline-rich domain and a leucine zipper-like motif.

Timothy J. Blake, M. Shapiro, Herbert C. Morse et al. · PubMed · 1991 · 239 citations

Life Sciences, Genetics, Molecular Biology +7

The truncation that generated the v‐cbl oncogene reveals an ability for nuclear transport, DNA binding and acute transformation.

Timothy J. Blake, K. G. Heath, Wallace Y. Langdon · The EMBO Journal · 1993 · 109 citations · Full text

Medicine, Cancer Biology, Molecular Biology +13

Human lymphocytes aged in vivo have reduced levels of methylation in transcriptionally active and inactive DNA

R. D. Drinkwater, Timothy J. Blake, Alexander A. Morley et al. · Mutation Research/DNAging · 1989 · 78 citations

Life Sciences, Genetics, Molecular Biology +12

Development and SAR of functionally selective allosteric modulators of GABAA receptors

Cristóbal Alhambra, Chris Becker, Timothy J. Blake et al. · Bioorganic & Medicinal Chemistry · 2011 · 51 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +14

(H+-K+)-ATPase inhibiting 2-[(2-pyridylmethyl)sulfinyl]benzimidazoles. 2. The reaction cascade induced by treatment with acids. Formation of 5H-pyrido[1',2':4,5][1,2,4]thiadiazino[2,3-a]benzimidazol-13-ium salts and their reactions with thiols

Joerg Senn‐Bilfinger, U. KRUEGER, Ernst Sturm et al. · The Journal of Organic Chemistry · 1987 · 48 citations

Life Sciences, Biochemistry, Chemistry +8