Grant M. Vaught

The Potent BACE1 Inhibitor LY2886721 Elicits Robust Central Aβ Pharmacodynamic Responses in Mice, Dogs, and Humans

Patrick C. May, Brian A. Willis, Stephen L. Lowe et al. · Journal of Neuroscience · 2015 · 195 citations · Full text

Amyloid β, Neurodegenerative Diseases, Amyloid Lowering +15

2-Chloro-4-[[(1<i>R</i>,2<i>R</i>)-2-hydroxy-2-methyl-cyclopentyl]amino]-3-methyl-benzonitrile: A Transdermal Selective Androgen Receptor Modulator (SARM) for Muscle Atrophy

Ashraf Saeed, Grant M. Vaught, Kostas Gavardinas et al. · Journal of Medicinal Chemistry · 2015 · 39 citations · Full text

Compound 6, Pharmacotherapy, Dermatology +19

A novel class of AMPA receptor allosteric modulators. Part 1: Design, synthesis, and SAR of 3-aryl-4-cyano-5-substituted-heteroaryl-2-carboxylic acid derivatives

Maria-Carmen Fernandez, Ana M. Castaño‐León, Esteban Domı́nguez et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 21 citations · Full text

Molecular Pharmacology, Biochemistry, Functional Selectivity +8

O1‐06‐03: Preclinical characterization of LY2886721: A BACE1 inhibitor in clinical development for early Alzheimer's disease

Patrick C. May, Leonard N. Boggs, Richard A. Brier et al. · Alzheimer s & Dementia · 2012 · 12 citations · Full text

Neurochemical Biomarkers, Bace1 Inhibitor, Social Sciences +19