Jaap A. Joles

Toll-Like Receptor 4 Mediates Maladaptive Left Ventricular Remodeling and Impairs Cardiac Function After Myocardial Infarction

Leo Timmers, Joost P. G. Sluijter, J. Karlijn van Keulen et al. · Circulation Research · 2007 · 341 citations · Full text

Life Sciences, Cardiology, Immunology +14

The renal hemodynamic effects of the SGLT2 inhibitor dapagliflozin are caused by post-glomerular vasodilatation rather than pre-glomerular vasoconstriction in metformin-treated patients with type 2 diabetes in the randomized, double-blind RED trial

Erik J.M. van Bommel, Marcel H.A. Muskiet, Michaël J.B. van Baar et al. · Kidney International · 2019 · 341 citations · Full text

Medicine, Pharmacology, Pharmacotherapy +16

FAN1 mutations cause karyomegalic interstitial nephritis, linking chronic kidney failure to defective DNA damage repair

Weibin Zhou, Edgar A. Otto, Andrew Cluckey et al. · Nature Genetics · 2012 · 244 citations · Full text

Medicine, Genetics, Molecular Genetics +16

Multiple common comorbidities produce left ventricular diastolic dysfunction associated with coronary microvascular dysfunction, oxidative stress, and myocardial stiffening

Oana Sorop, Ilkka Heinonen, Matthijs van Kranenburg et al. · Cardiovascular Research · 2018 · 207 citations · Full text

Veterinary Medicine, Cardiology, Inflammation +12

Human Embryonic Mesenchymal Stem Cell-Derived Conditioned Medium Rescues Kidney Function in Rats with Established Chronic Kidney Disease

Arianne van Koppen, Jaap A. Joles, Bas W. M. van Balkom et al. · PLoS ONE · 2012 · 206 citations · Full text

Medicine, Physiology, Cell Therapy +9