Jubrail Rahil

MGCD0103, a novel isotype-selective histone deacetylase inhibitor, has broad spectrum antitumor activity <i>in vitro</i> and <i>in vivo</i>

Marielle Fournel, Claire Bonfils, Yu Hou et al. · Molecular Cancer Therapeutics · 2008 · 333 citations · Full text

Tumor Biology, Inhibitory Activity, Medicine +13

Novel Aminophenyl Benzamide-Type Histone Deacetylase Inhibitors with Enhanced Potency and Selectivity

Oscar Moradei, Tammy C. Mallais, Sylvie Fréchette et al. · Journal of Medicinal Chemistry · 2007 · 161 citations · Full text

Inhibitory Activity, Medicinal Chemistry, Bioorganic Chemistry +15

Crystallographic Structure of a Phosphonate Derivative of the Enterobacter cloacae P99 Cephalosporinase: Mechanistic Interpretation of a .beta.-Lactamase Transition-State Analog

Emil B. Lobkovsky, Eric M. Billings, Paul C. Moews et al. · Biochemistry · 1994 · 142 citations

Discovery of <i>N</i>-(2-Aminophenyl)-4-[(4-pyridin-3-ylpyrimidin-2-ylamino)methyl]benzamide (MGCD0103), an Orally Active Histone Deacetylase Inhibitor

Nancy Zhou, Oscar Moradei, Stéphane Raeppel et al. · Journal of Medicinal Chemistry · 2008 · 108 citations · Full text

Compound 8, Chemoprevention Strategy, Pharmacotherapy +18

Novel HDAC6 isoform selective chiral small molecule histone deacetylase inhibitors

David Smil, Sukhdev Manku, Yves Chantigny et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 81 citations · Full text

Molecular Pharmacology, Chromatin, Biochemistry +6