An investigation into the formation of stable, protein-reactive and cytotoxic metabolites from tacrine in vitro

Stephen F. Madden, Thomas F. Woolf, William F. Pool, +1

Biochemical Pharmacology

BiochemistryMedicineToxicologyExperimental ToxicologyPharmacology +3

Genetic analysis of microsomal epoxide hydrolase in patients with carbamazepine hypersensitivity

Victoria J. Green, Munir Pirmohamed, Neil R. Kitteringham, +5

Biochemical Pharmacology

Carbamazepine HypersensitivityGenetic AnalysisAllergyMicrosomal Epoxide HydrolaseMedicine +5

An investigation of the formation of cytotoxic, genotoxic, protein-reactive and stable metabolites from naphthalene by human liver microsomes

Malcolm D. Tingle, Munir Pirmohamed, Elizabeth Templeton, +4

Biochemical Pharmacology

BiochemistryMedicineLiver PhysiologyToxicologyHuman Liver Microsomes +10

Amodiaquine accumulation in Plasmodium falciparum as a possible explanation for its superior antimalarial activity over chloroquine

Shaun R. Hawley, Patrick G. Bray, B.Kevin Park, +1

Molecular and Biochemical Parasitology

Antiparasitic AgentAmodiaquine AccumulationMedicineMalariaParasite Genomics +5

Co(thd)2: a superior catalyst for aerobic epoxidation and hydroperoxysilylation of unactivated alkenes: application to the synthesis of spiro-1,2,4-trioxanes

Paul M. O’Neill, Stephen Hindley, Matthew D. Pugh, +6

Tetrahedron Letters

Chemical EngineeringEngineeringAlkene MetathesisOrganic ChemistryCatalysis +5

A carbonyl oxide route to antimalarial yingzhaosu A analogues: Synthesis and antimalarial activity

Paul M. O' Neill, Natalie L. Searle, Kaylene J. Raynes, +5

Tetrahedron Letters

Antimalarial YingzhaosuPhytoalexinMedicinal ChemistryNatural Product SynthesisEngineering +12

Drug protein conjugates—I. A study of the covalent binding of [14C]captopril to plasma proteins in the rat

B.Kevin Park, Peter Grabowski, John H.K. Yeung, +1

Biochemical Pharmacology

Molecular PharmacologyCovalent BindingDrug TargetBiochemistryMedicine +5

The effect of enzyme induction on the cytochrome P450-mediated bioactivation of carbamazepine by mouse liver microsomes

Munir Pirmohamed, Neil R. Kitteringham, Alasdair Breckenridge, +1

Biochemical Pharmacology

Cytochrome P450-mediated BioactivationPharmacological StudyBiochemistryMedicineMouse Liver Microsomes +6

Regioselective Mukaiyama hydroperoxysilylation of 2-alkyl- or 2-aryl-prop-2-en-1-ols: application to a new synthesis of 1,2,4-trioxanes

Paul M. O’Neill, Matthew D. Pugh, Jill Davies, +2

Tetrahedron Letters

Chemical EngineeringEngineeringRegioselective Mukaiyama HydroperoxysilylationOrganic ChemistryNew Synthesis +4

A comparative study of the effects of warfarin and brodifacoum on the relationship between vitamin K1, metabolism and clotting factor activity in warfarin-susceptible and warfarin-resistant rats

Jacqueline B. Leck, B.Kevin Park

Biochemical Pharmacology

Vitamin K AntagonistsThrombosisInflammationMedicineHematology +12