An investigation into the formation of stable, protein-reactive and cytotoxic metabolites from tacrine in vitro

The Carbon Monoxide-binding Pigment of Liver Microsomes

Tsuneo Omura, Ryo Sato · Journal of Biological Chemistry · 1964 · 11.8K citations · Full text

Life Sciences, Biochemistry, Chemistry +8

ACETAMINOPHEN-INDUCED HEPATIC NECROSIS. I. ROLE OF DRUG METABOLISM

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Oral Tetrahydroaminoacridine in Long-Term Treatment of Senile Dementia, Alzheimer Type

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Medicine, Neurology, Pharmacology +15

N-acetyl-p-benzoquinone imine: a cytochrome P-450-mediated oxidation product of acetaminophen.

David C. Dahlin, Gerald T. Miwa, Albert Lu et al. · Proceedings of the National Academy of Sciences · 1984 · 1.1K citations

Medicine, Pharmacology, Toxicology +16

A controlled trial of tacrine in Alzheimer's disease. The Tacrine Study Group

Martin Farlow · JAMA · 1992 · 543 citations

Medicine, Pharmacology, Pharmacotherapy +13