ChiehYing Chang

Discovery of 6-Fluoro-5-(<i>R</i>)-(3-(<i>S</i>)-(8-fluoro-1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4<i>H</i>)-yl)-2-methylphenyl)-2-(<i>S</i>)-(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1<i>H</i>-carbazole-8-carboxamide (BMS-986142): A Reversible Inhibitor of Bruton’s Tyrosine Kinase (BTK) Conformationally Constrained by Two Locked Atropisomers

Scott H. Watterson, George V. De Lucca, Qing Shi et al. · Journal of Medicinal Chemistry · 2016 · 146 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +17

Discovery of a 2,4-Disubstituted Pyrrolo[1,2-<i>f</i>][1,2,4]triazine Inhibitor (BMS-754807) of Insulin-like Growth Factor Receptor (IGF-1R) Kinase in Clinical Development

Mark D. Wittman, Joan M. Carboni, Yang Zheng et al. · Journal of Medicinal Chemistry · 2009 · 94 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +9

Small Molecule Reversible Inhibitors of Bruton’s Tyrosine Kinase (BTK): Structure–Activity Relationships Leading to the Identification of 7-(2-Hydroxypropan-2-yl)-4-[2-methyl-3-(4-oxo-3,4-dihydroquinazolin-3-yl)phenyl]-9<i>H</i>-carbazole-1-carboxamide (BMS-935177)

George V. De Lucca, Qing Shi, Qingjie Liu et al. · Journal of Medicinal Chemistry · 2016 · 52 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Purine derivatives as potent Bruton’s tyrosine kinase (BTK) inhibitors for autoimmune diseases

Qing Shi, Andrew J. Tebben, Alaric J. Dyckman et al. · Bioorganic & Medicinal Chemistry Letters · 2014 · 39 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +15

Discovery of azetidinone acids as conformationally-constrained dual PPARα/γ agonists

Wei Wang, Pratik Devasthale, Dennis Farrelly et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 37 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14