Concepedia

Thomas H. McLean

TH

Statistics

Publications

6

Citations

622

H-Index

6

Active since

2005

Affiliations

Purdue University West Lafayette(Current)

Relay Therapeutics (United States)

D. E. Shaw Research

Thomas H. McLean is an author at Purdue University West Lafayette specializing in chromatin, chromatin function, and chromatin structure.

ORCID

Top concepts

Publications per year

2005–2024

6

Publications

6

Human HDAC7 Harbors a Class IIa Histone Deacetylase-specific Zinc Binding Motif and Cryptic Deacetylase Activity

A. Schuetz, Jinrong Min, Abdellah Allali‐Hassani et al. · Journal of Biological Chemistry · 2008 · 254 citations · Full text

, , +20

1-Aminomethylbenzocycloalkanes:  Conformationally Restricted Hallucinogenic Phenethylamine Analogues as Functionally Selective 5-HT<sub>2A</sub>Receptor Agonists

Thomas H. McLean, Jason C. Parrish, M. Braden et al. · Journal of Medicinal Chemistry · 2006 · 113 citations · Full text

Sulfur-Substituted α-Alkyl Phenethylamines as Selective and Reversible MAO-A Inhibitors:  Biological Activities, CoMFA Analysis, and Active Site Modeling

Alejandra Gallardo‐Godoy, Angélica Fierro, Thomas H. McLean et al. · Journal of Medicinal Chemistry · 2005 · 99 citations · Full text

Discovery and Clinical Proof-of-Concept of RLY-2608, a First-in-Class Mutant-Selective Allosteric PI3Kα Inhibitor That Decouples Antitumor Activity from Hyperinsulinemia

Andreas Varkaris, Ermira Pazolli, Hakan Günaydin et al. · Cancer Discovery · 2023 · 80 citations · Full text

Discovery of lirafugratinib (RLY-4008), a highly selective irreversible small-molecule inhibitor of FGFR2

Heike Schönherr, Pelin Ayaz, Alexander M. Taylor et al. · Proceedings of the National Academy of Sciences · 2024 · 53 citations · Full text

1–5 of 6