Familial Hemophagocytic Lymphohistiocytosis Type 5 (FHL-5) Is Caused by Mutations in Munc18-2 and Impaired Binding to Syntaxin 11

Udo zur Stadt, Jan Rohr, Wenke Seifert, +13

The American Journal of Human Genetics

Impaired BindingMendelian DisorderAutoimmune DiseaseGenetic DisorderPathogenesis +9

Heterogeneous Differentiation Patterns of Individual CD8 ⁺ T Cells

Carmen Gerlach, Jan Rohr, Leïla Perié, +9

Science

Autoimmune DiseaseT Cell HeterogeneityLymphocyte DevelopmentT CellsIndividual Mouse Cd8 +13

Oncogenic JAK2 ^V617F causes PD-L1 expression, mediating immune escape in myeloproliferative neoplasms

Alessandro Prestipino, Alica Joana Emhardt, Konrad Aumann, +46

Science Translational Medicine

Lethal hemophagocytic lymphohistiocytosis in Hermansky-Pudlak syndrome type II

Anselm Enders, Barbara Zieger, Klaus Schwarz, +12

Blood

Atypical familial hemophagocytic lymphohistiocytosis due to mutations in UNC13D and STXBP2 overlaps with primary immunodeficiency diseases

Jan Rohr, Karin Beutel, Andrea Maul‐Pavicic, +17

Haematologica

Hyperactive mTOR pathway promotes lymphoproliferation and abnormal differentiation in autoimmune lymphoproliferative syndrome

Simon Völkl, Anne Rensing‐Ehl, Andrea Allgäuer, +21

Blood

Cytomegalovirus subverts macrophage identity

Sebastian Baasch, Piero Giansanti, Julia Kolter, +18

Cell

PathogenesisViral PathogenesisImmunologyAntiviral ResponseVirology +3

Reduced memory B cells in patients with hyper IgE syndrome

Carsten Speckmann, Anselm Enders, Cristina Woellner, +15

Clinical Immunology

AllergyAutoimmune DiseaseImmunologyMemoryAutoimmunity +5

Quorum Regulation via Nested Antagonistic Feedback Circuits Mediated by the Receptors CD28 and CTLA-4 Confers Robustness to T Cell Population Dynamics

Simon Zenke, Margriet M. Palm, Julia Braun, +10

Immunity

Ctla-4 Confers RobustnessSignal TransductionReceptors Cd28MedicineCell Interaction +7

Clinical and immunologic consequences of a somatic reversion in a patient with X-linked severe combined immunodeficiency

Carsten Speckmann, Ulrich Pannicke, Elisabeth Wiech, +12

Blood