Combination of Lenvatinib and Pembrolizumab Is an Effective Treatment Option for Anaplastic and Poorly Differentiated Thyroid Carcinoma

Christine Dierks, Jochen Seufert, Konrad Aumann, +18

Thyroid

Oncogenic JAK2 ^V617F causes PD-L1 expression, mediating immune escape in myeloproliferative neoplasms

Alessandro Prestipino, Alica Joana Emhardt, Konrad Aumann, +46

Science Translational Medicine

Demethylating therapy increases anti-CD123 CAR T cell cytotoxicity against acute myeloid leukemia

Nadia El Khawanky, Amy Hughes, Wenbo Yu, +17

Nature Communications

MicroRNA-146a regulates immune-related adverse events caused by immune checkpoint inhibitors

Dominik Marschner, Martina Falk, Nóra Rebeka Jávorniczky, +16

JCI Insight

MPN patients harbor recurrent truncating mutations in transcription factor NF-E2

Jonas S. Jutzi, Ruzhica Bogeska, Gorica Nikoloski, +15

The Journal of Experimental Medicine

Transcriptional RegulationSystems BiologyTranscription Factor Nf-e2EngineeringSomatic Variant +13

Lactate-Dehydrogenase 5 is overexpressed in non-small cell lung cancer and correlates with the expression of the transketolase-like protein 1

Gian Kayser, Ahmad Kassem, Wulf Sienel, +7

Diagnostic Pathology

A novel murine model of myeloproliferative disorders generated by overexpression of the transcription factor NF-E2

Kai Kaufmann, Albert Gründer, Tobias Hadlich, +20

The Journal of Experimental Medicine

Histone ModificationsMixed-phenotype Acute LeukemiaImmunologyMyeloid NeoplasiaHematological Malignancy +16

Insulin-like growth factor-1 receptor (IGF1R) as a novel target in chronic lymphocytic leukemia

Niuscha Yaktapour, Rudolf Übelhart, Julia Schüler, +8

Blood

Gab2 signaling in chronic myeloid leukemia cells confers resistance to multiple Bcr-Abl inhibitors

Franziska U. Wöhrle, Sebastian Halbach, Konrad Aumann, +12

Leukemia

Hematological MalignancyTumor BiologyMixed-phenotype Acute LeukemiaBcr-abl InhibitorsCell Biology +5

Transitioning the Molecular Tumor Board from Proof of Concept to Clinical Routine: A German Single-Center Analysis

Rouven Hoefflin, Adriana Lazarou, Maria Elena Hess, +40

Cancers

Surgical OncologyClinical RoutineMtb PatientsCancer ManagementPathology +20