Nélio Gonçalves

Early synaptic deficits in the APP/PS1 mouse model of Alzheimer’s disease involve neuronal adenosine A2A receptors

Silvia Viana da Silva, Matthias G. Haberl, Pei Zhang et al. · Nature Communications · 2016 · 239 citations · Full text

Activation of microglial cells triggers a release of brain-derived neurotrophic factor (BDNF) inducing their proliferation in an adenosine A2A receptor-dependent manner: A2A receptor blockade prevents BDNF release and proliferation of microglia

Catarina A. Gomes, Raquel Ferreira, Jimmy George et al. · Journal of Neuroinflammation · 2013 · 222 citations · Full text

Optogenetic activation of intracellular adenosine A2A receptor signaling in the hippocampus is sufficient to trigger CREB phosphorylation and impair memory

Ping Li, Daniel Rial, Paula M. Canas et al. · Molecular Psychiatry · 2015 · 137 citations · Full text

Impair Memory, Neurophysiology, Medicine +11

Synaptic and memory dysfunction in a β-amyloid model of early Alzheimer's disease depends on increased formation of ATP-derived extracellular adenosine

Francisco Q. Gonçalves, João Pedro Lopes, Henrique B. Silva et al. · Neurobiology of Disease · 2019 · 102 citations · Full text

Adenosine A2A Receptors in the Amygdala Control Synaptic Plasticity and Contextual Fear Memory

Ana Patrícia Simões, Nuno J. Machado, Nélio Gonçalves et al. · Neuropsychopharmacology · 2016 · 88 citations · Full text

Contextual Fear Memory, Synaptic Plasticity, Cognitive Science +13