Angela Styhler

Development of a Liver-Targeted Stearoyl-CoA Desaturase (SCD) Inhibitor (MK-8245) to Establish a Therapeutic Window for the Treatment of Diabetes and Dyslipidemia

Renata M. Oballa, Liette Belair, W. Cameron Black et al. · Journal of Medicinal Chemistry · 2011 · 142 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Preferential Inhibition of T Helper 1, but Not T Helper 2, Cytokines in Vitro by L-826,141 [4-{2-(3,4-Bisdifluromethoxyphenyl)-2-{4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-phenyl]-ethyl}-3-methylpyridine-1-oxide], a Potent and Selective Phosphodiesterase 4 Inhibitor

David Claveau, S L Chen, Stephen J. O’Keefe et al. · Journal of Pharmacology and Experimental Therapeutics · 2004 · 101 citations

Medicine, Medicinal Chemistry, Pharmacology +9

The Discovery of Setileuton, a Potent and Selective 5-Lipoxygenase Inhibitor

Yves Ducharme, Marc Blouin, Christine Brideau et al. · ACS Medicinal Chemistry Letters · 2010 · 80 citations

Pharmacy, Medicinal Chemistry, Pharmacology +15

The effects of phosphodiesterase type 4 inhibitors on tumour necrosis factor‐<i>α</i> and leukotriene B₄ in a novel human whole blood assay

Christine Brideau, Carlo van Staden, Angela Styhler et al. · British Journal of Pharmacology · 1999 · 69 citations · Full text

Medicine, Pharmacology, Biochemical Pharmacology +12

Optimization of a Tertiary Alcohol Series of Phosphodiesterase-4 (PDE4) Inhibitors:  Structure−Activity Relationship Related to PDE4 Inhibition and Human Ether-a-go-go Related Gene Potassium Channel Binding Affinity

Richard W. Friesen, Yves Ducharme, Richard G. Ball et al. · Journal of Medicinal Chemistry · 2003 · 66 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17