The let-7 family of microRNAs inhibits Bcl-xL expression and potentiates sorafenib-induced apoptosis in human hepatocellular carcinoma

Satoshi Shimizu, Tetsuo Takehara, Hayato Hikita, +10

Journal of Hepatology

Tumor BiologySorafenib-induced ApoptosisHuman Hepatocellular CarcinomaLiver PhysiologyImmunology +11

Inhibition of autophagy potentiates the antitumor effect of the multikinase inhibitor sorafenib in hepatocellular carcinoma

Satoshi Shimizu, Tetsuo Takehara, Hayato Hikita, +11

International Journal of Cancer

Loss of signal transducer and activator of transcription 5 leads to hepatosteatosis and impaired liver regeneration†

Yongzhi Cui, Atsushi Hosui, Rui Sun, +7

Hepatology

Increases in p53 expression induce CTGF synthesis by mouse and human hepatocytes and result in liver fibrosis in mice

Takahiro Kodama, Tetsuo Takehara, Hayato Hikita, +18

Journal of Clinical Investigation

Liver FibrosisPathologyCell DeathTumor BiologyHepatobiliary Tumor +18

The Bcl-Xl Inhibitor, ABT-737, Efficiently Induces Apoptosis and Suppresses Growth of Hepatoma Cells in Combination with Sorafenib

Hayato Hikita, Tetsuo Takehara, Satoshi Shimizu, +11

Hepatology

Sorafenib inhibits the shedding of major histocompatibility complex class I–related chain A on hepatocellular carcinoma cells by down‐regulating a disintegrin and metalloproteinase 9†

Keisuke Kohga, Tetsuo Takehara, Tomohide Tatsumi, +4

Hepatology

Thrombocytopenia Exacerbates Cholestasis-Induced Liver Fibrosis in Mice

Takahiro Kodama, Tetsuo Takehara, Hayato Hikita, +7

Gastroenterology

InflammationLiver FibrosisAutoimmune DiseaseHepatologyLiver Physiology +11

Mcl-1 and Bcl-xL Cooperatively Maintain Integrity of Hepatocytes in Developing and Adult Murine Liver†

Hayato Hikita, Tetsuo Takehara, Satoshi Shimizu, +12

Hepatology

Loss of STAT5 causes liver fibrosis and cancer development through increased TGF-β and STAT3 activation

Atsushi Hosui, Akiko Kimura, Daisuke Yamaji, +3

The Journal of Experimental Medicine

Loss of Sexually Dimorphic Liver Gene Expression upon Hepatocyte-Specific Deletion of Stat5a-Stat5b Locus

Minita G. Holloway, Yongzhi Cui, Ekaterina V. Laz, +3

Endocrinology