Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

Jung‐Hyun Park, Stanley Adoro, Terry I. Guinter, +11

Nature Immunology

Autoimmune DiseaseLymphocyte DevelopmentAdaptive Immune SystemImmunologyIntrathymic Cytokines +8

T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial

Daniel W Lee, James N. Kochenderfer, Maryalice Stetler‐Stevenson, +15

The Lancet

T CellsT-regulatory CellImmunologyHematologyAutoimmunity +7

Disruption of CXCR2-Mediated MDSC Tumor Trafficking Enhances Anti-PD1 Efficacy

Steven L. Highfill, Yongzhi Cui, Amber Giles, +5

Science Translational Medicine

CAR T Cells Targeting B7-H3, a Pan-Cancer Antigen, Demonstrate Potent Preclinical Activity Against Pediatric Solid Tumors and Brain Tumors

Robbie G. Majzner, Johanna Theruvath, Anandani Nellan, +24

Clinical Cancer Research

Inactivation of Stat5 in Mouse Mammary Epithelium during Pregnancy Reveals Distinct Functions in Cell Proliferation, Survival, and Differentiation

Yongzhi Cui, Gregory Riedlinger, Keiko Miyoshi, +5

Molecular and Cellular Biology

Developmental BiologyTissue DevelopmentGeneticsMouse Mammary EpitheliumSignal Transducers +13

Activation of PPAR γ and δ by conjugated linoleic acid mediates protection from experimental inflammatory bowel disease

Josep Bassaganya‐Riera, Kathryn Reynolds, Susan Martino‐Catt, +5

Gastroenterology

InflammationAnti-inflammatoryBiochemistryPpar γMedicine +5

Stat5a/b are essential for normal lymphoid development and differentiation

Zhengju Yao, Yongzhi Cui, Wendy T. Watford, +9

Proceedings of the National Academy of Sciences

Reduction of MDSCs with All-trans Retinoic Acid Improves CAR Therapy Efficacy for Sarcomas

Adrienne H. Long, Steven L. Highfill, Yongzhi Cui, +8

Cancer Immunology Research

Priming for T helper type 2 differentiation by interleukin 2–mediated induction of interleukin 4 receptor α-chain expression

Wei Liao, Dustin E. Schones, Jangsuk Oh, +5

Nature Immunology

InflammationInterleukin 2–MediatedCytokineAdaptive Immune SystemImmune Cell Development +12

Sirt3-mediated mitophagy regulates AGEs-induced BMSCs senescence and senile osteoporosis

Yuanyuan Guo, Xiong Jia, Yongzhi Cui, +6

Redox Biology

MitophagyAnti-agingBone Morphogenic ProteinSenile OsteoporosisCell Signaling +11