Ignacio Moraga

Exploiting a natural conformational switch to engineer an interleukin-2 ‘superkine’

Aron M. Levin, D.L. Bates, Aaron M. Ring et al. · Nature · 2012 · 538 citations · Full text

Inflammation, Cytokine, Signal Transduction +10

Structural Linkage between Ligand Discrimination and Receptor Activation by Type I Interferons

Christoph Thomas, Ignacio Moraga, Doron Levin et al. · Cell · 2011 · 351 citations

Ligand Discrimination, Signal Transduction, Functional Selectivity +12

Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15

Aaron M. Ring, Jian‐Xin Lin, Dan Feng et al. · Nature Immunology · 2012 · 235 citations · Full text

Inflammation, Cytokine, Autoimmune Disease +12

Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations

Stephan Wilmes, Maximillian Hafer, Joni Vuorio et al. · Science · 2020 · 181 citations · Full text

Receptor Dimers, Immunology, Molecular Biology +18

Tuning Cytokine Receptor Signaling by Re-orienting Dimer Geometry with Surrogate Ligands

Ignacio Moraga, Gerlinde Wernig, Stephan Wilmes et al. · Cell · 2015 · 167 citations · Full text

Inflammation, Cytokine, Re-orienting Dimer Geometry +10