Alzheimer's β-secretase, β-site amyloid precursor protein-cleaving enzyme, is responsible for cleavage secretion of a Golgi-resident sialyltransferase

Shinobu Kitazume, Yuriko Tachida, Ritsuko Oka, +3

Proceedings of the National Academy of Sciences

An aberrant sugar modification of <scp>BACE</scp> 1 blocks its lysosomal targeting in <scp>A</scp> lzheimer's disease

Yasuhiko Kizuka, Shinobu Kitazume, Reiko Fujinawa, +12

EMBO Molecular Medicine

Simultaneous determination of nucleotide sugars with ion-pair reversed-phase HPLC

Kazuki Nakajima, Shinobu Kitazume, Takashi Angata, +4

Glycobiology

Brain Endothelial Cells Produce Amyloid β from Amyloid Precursor Protein 770 and Preferentially Secrete the O-Glycosylated Form

Shinobu Kitazume, Yuriko Tachida, Masaki Kato, +8

Journal of Biological Chemistry

Protein SecretionGlycobiologyO-glycosylated FormAmyloid Precursor ProteinNeuroinflammation +17

Characterization of α2,6-Sialyltransferase Cleavage by Alzheimer's β-Secretase (BACE1)

Shinobu Kitazume, Yuriko Tachida, Ritsuko Oka, +7

Journal of Biological Chemistry

α2,6-Sialic Acid on Platelet Endothelial Cell Adhesion Molecule (PECAM) Regulates Its Homophilic Interactions and Downstream Antiapoptotic Signaling

Shinobu Kitazume, Rie Imamaki, Kazuko Ogawa, +7

Journal of Biological Chemistry

A Single Dose of Lipopolysaccharide into Mice with Emphysema Mimics Human Chronic Obstructive Pulmonary Disease Exacerbation as Assessed by Micro-Computed Tomography

Satoshi Kobayashi, Reiko Fujinawa, Fumi Ota, +13

American Journal of Respiratory Cell and Molecular Biology

InflammationAsthmaInflammatory CellsAllergyInflammatory Lung Disease +11

In Vivo Cleavage of α2,6-Sialyltransferase by Alzheimer β-Secretase

Shinobu Kitazume, Kazuhiro Nakagawa, Ritsuko Oka, +11

Journal of Biological Chemistry

Interleukin‐1β up‐regulates TACE to enhance α‐cleavage of APP in neurons: resulting decrease in Aβ production

Yuriko Tachida, Kazuhiro Nakagawa, Takashi Saito, +9

Journal of Neurochemistry

Bisecting GlcNAc modification stabilizes BACE1 protein under oxidative stress conditions

Yasuhiko Kizuka, Miyako Nakano, Shinobu Kitazume, +3

Biochemical Journal