Helen Poska

Dementia-related Bri2 BRICHOS is a versatile molecular chaperone that efficiently inhibits Aβ42 toxicity in <i>Drosophila</i>

Helen Poska, Martin Haslbeck, Firoz Roshan Kurudenkandy et al. · Biochemical Journal · 2016 · 54 citations

Genetics, Amyloid-β Peptide, Molecular Biology +23

Recombinant Bri3 BRICHOS domain is a molecular chaperone with effect against amyloid formation and non-fibrillar protein aggregation

Helen Poska, Axel Leppert, Helene Tigro et al. · Scientific Reports · 2020 · 21 citations · Full text

Thioredoxin-80 protects against amyloid-beta pathology through autophagic-lysosomal pathway regulation

Gorka Gereñu, Torbjörn Persson, Julen Goikolea et al. · Molecular Psychiatry · 2019 · 18 citations

Cell Autophagy, Alzheimer's Disease, Autoimmune Disease +8

Amyloid β25–35 induced ROS-burst through NADPH oxidase is sensitive to iron chelation in microglial Bv2 cells

Kristin Part, Kai Künnis-Beres, Helen Poska et al. · Brain Research · 2015 · 16 citations

Inflammation, Amyloid β25–35, Nadph Oxidase +12

Abilities of the BRICHOS domain to prevent neurotoxicity and fibril formation are dependent on a highly conserved Asp residue

Gefei Chen, Yuniesky Andrade‐Talavera, Xueying Zhong et al. · RSC Chemical Biology · 2022 · 16 citations · Full text