Bri2 BRICHOS client specificity and chaperone activity are governed by assembly state

Gefei Chen, Axel Abelein, Harriet E. Nilsson, +12

Nature Communications

Augmentation of Bri2 molecular chaperone activity against amyloid-β reduces neurotoxicity in mouse hippocampus in vitro

Gefei Chen, Yuniesky Andrade‐Talavera, Simone Tambaro, +10

Communications Biology

Protein AssemblyMolecular BiologyAlzheimer's DiseaseProtein FoldingDegenerative Pathology +16

Liquid–Liquid Phase Separation Primes Spider Silk Proteins for Fiber Formation via a Conditional Sticker Domain

Axel Leppert, Gefei Chen, Dilraj Lama, +8

Nano Letters

Charge Engineering Reveals the Roles of Ionizable Side Chains in Electrospray Ionization Mass Spectrometry

Mia Abramsson, Cagla Sahin, Jonathan T. S. Hopper, +18

JACS Au

Maresin 1 attenuates pro‐inflammatory activation induced by β‐amyloid and stimulates its uptake

Ying Wang, Axel Leppert, Shuai Tan, +4

Journal of Cellular and Molecular Medicine

Dissociation of a BRICHOS trimer into monomers leads to increased inhibitory effect on Aβ42 fibril formation

Henrik Biverstål, Lisa Dolfe, Erik Hermansson, +5

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

Protein ChemistryProtein FunctionAβ42 Fibril FormationBiochemistryProtein Assembly +8

Recombinant BRICHOS chaperone domains delivered to mouse brain parenchyma by focused ultrasound and microbubbles are internalized by hippocampal and cortical neurons

Lorena Galán-Acosta, Carlos Sierra, Axel Leppert, +8

Molecular and Cellular Neuroscience

Brichos DomainsCellular NeurobiologySocial SciencesNeuroinflammationAlzheimer's Disease +16

Blood–brain and blood–cerebrospinal fluid passage of BRICHOS domains from two molecular chaperones in mice

Simone Tambaro, Lorena Galán-Acosta, Axel Leppert, +5

Journal of Biological Chemistry

Recombinant Bri3 BRICHOS domain is a molecular chaperone with effect against amyloid formation and non-fibrillar protein aggregation

Helen Poska, Axel Leppert, Helene Tigro, +6

Scientific Reports

Smallest Secondary Nucleation Competent Aβ Aggregates Probed by an ATP-Independent Molecular Chaperone Domain

Axel Leppert, Ann Tiiman, Nina Kronqvist, +4

Biochemistry

Protein AssemblyMolecular BiologyPeptide ScienceAnalytical UltracentrifugationProtein Folding +16