Job de Lange

MDM4 is a key therapeutic target in cutaneous melanoma

Agnieszka Gembarska, Flavie Luciani, Clare G. Fedele et al. · Nature Medicine · 2012 · 300 citations · Full text

Tumor Biology, Melanoma, Cutaneous Melanoma +4

ELOF1 is a transcription-coupled DNA repair factor that directs RNA polymerase II ubiquitylation

Yana van der Weegen, Klaas de Lint, Diana van den Heuvel et al. · Nature Cell Biology · 2021 · 103 citations · Full text

Chromatin, Genome Instability, Natural Sciences +8

Synergistic growth inhibition based on small-molecule p53 activation as treatment for intraocular melanoma

Job de Lange, Long V. Ly, Kirsten Lodder et al. · Oncogene · 2011 · 62 citations

Small-molecule P53 Activation, Ophthalmology, Photocarcinogenesis +8

Warsaw Breakage Syndrome associated DDX11 helicase resolves G-quadruplex structures to support sister chromatid cohesion

Janne J. M. van Schie, Atiq Faramarz, Jesper A. Balk et al. · Nature Communications · 2020 · 56 citations · Full text

Defective sister chromatid cohesion is synthetically lethal with impaired APC/C function

Job de Lange, Atiq Faramarz, Anneke B. Oostra et al. · Nature Communications · 2015 · 54 citations · Full text