DDX39B drives colorectal cancer progression by promoting the stability and nuclear translocation of PKM2

Gang Zhao, Hang Yuan, Li Qin, +8

Signal Transduction and Targeted Therapy

Epigenetic RegulationCell SignalingPkm2 BindingMedicineColorectal Cancer +13

Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Target Binding Ligands

Ziqian Wang, Nianzhe He, Zongwei Guo, +8

Journal of Medicinal Chemistry

Loss of TRIM31 promotes breast cancer progression through regulating K48- and K63-linked ubiquitination of p53

Yafei Guo, Qin Li, Gang Zhao, +8

Cell Death and Disease

Arginine promotes skeletal muscle fiber type transformation from fast-twitch to slow-twitch via Sirt1/AMPK pathway

Xiaoling Chen, Yafei Guo, Gang Jia, +3

The Journal of Nutritional Biochemistry

Systems BiologySignal TransductionMolecular PhysiologyMuscle FunctionSkeletal Muscle +5

Ferulic acid regulates muscle fiber type formation through the Sirt1/AMPK signaling pathway

Xiaoling Chen, Yafei Guo, Gang Jia, +3

Food & Function

Small-molecule inhibitor targeting the Hsp70-Bim protein–protein interaction in CML cells overcomes BCR-ABL-independent TKI resistance

Ting Song, Yafei Guo, Zuguang Xue, +10

Leukemia

Protein FunctionSignal TransductionCell RegulationReceptor Tyrosine KinaseImmunology +7

Alkannin induces cytotoxic autophagy and apoptosis by promoting ROS-mediated mitochondrial dysfunction and activation of JNK pathway

Qianwen Zheng, Qin Li, Gang Zhao, +7

Biochemical Pharmacology

Cell AutophagyMitophagyMitochondrial FunctionRos-mediated Mitochondrial DysfunctionApoptosis +9

Pin1 inhibition exerts potent activity against acute myeloid leukemia through blocking multiple cancer-driving pathways

Xiaolan Lian, Yu‐Min Lin, Shingo Kozono, +18

Journal of Hematology & Oncology

Bim transfer between Bcl-2-like protein and Hsp70 underlines Bcl-2/Hsp70 crosstalk to regulate apoptosis

Hong Zhang, Zongwei Guo, Yafei Guo, +4

Biochemical Pharmacology

Signal TransductionSignaling PathwayCell RegulationApoptosisCell Death +7

A novel Hsp70 inhibitor specifically targeting the cancer-related Hsp70-Bim protein-protein interaction

Ziqian Wang, Ting Song, Zongwei Guo, +11

European Journal of Medicinal Chemistry

Protein FunctionMedicineNatural SciencesMolecular BiologyNovel Hsp70 Inhibitor +8