Juan Pablo Cueva

Extensive Rigid Analogue Design Maps the Binding Conformation of Potent <i>N</i>-Benzylphenethylamine 5-HT_2A Serotonin Receptor Agonist Ligands

Jose I. Juncosa, Martin Hansen, Lisa A. Bonner et al. · ACS Chemical Neuroscience · 2012 · 56 citations · Full text

Combinatorial Chemistry, Drug Target, Optimal Binding Conformation +17

<i>trans</i>-2,3-Dihydroxy-6a,7,8,12b-tetrahydro-6<i>H</i>-chromeno[3,4-<i>c</i>]isoquinoline:  Synthesis, Resolution, and Preliminary Pharmacological Characterization of a New Dopamine D₁Receptor Full Agonist

Juan Pablo Cueva, Gianfabio Giorgioni, Russell Alan Grubbs et al. · Journal of Medicinal Chemistry · 2006 · 49 citations · Full text

C7β-Methyl Analogues of the Orvinols: The Discovery of Kappa Opioid Antagonists with Nociceptin/Orphanin FQ Peptide (NOP) Receptor Partial Agonism and Low, or Zero, Efficacy at Mu Opioid Receptors

Juan Pablo Cueva, Christopher Roche, Mehrnoosh Ostovar et al. · Journal of Medicinal Chemistry · 2015 · 24 citations · Full text

Drug Target, Peptide Science, Pharmacotherapy +19

Synthesis and In Vitro Opioid Receptor Functional Antagonism of Methyl-Substituted Analogues of (3<i>R</i>)-7-Hydroxy-<i>N</i>-[(1<i>S</i>)-1-{[(3<i>R</i>,4<i>R</i>)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide (JDTic)

Juan Pablo Cueva, Tingwei Cai, S. Wayne Mascarella et al. · Journal of Medicinal Chemistry · 2009 · 20 citations

Drug Target, Jdtic Structure, Methyl-substituted Analogues +16

Probing the Steric Space at the Floor of the D₁ Dopamine Receptor Orthosteric Binding Domain: 7α-, 7β-, 8α-, and 8β-Methyl Substituted Dihydrexidine Analogues

Juan Pablo Cueva, Alejandra Gallardo‐Godoy, Jose I. Juncosa et al. · Journal of Medicinal Chemistry · 2011 · 18 citations · Full text

Engineering, Organic Chemistry, Small Molecules +17