Jose I. Juncosa

Design and Mechanism of (<i>S</i>)-3-Amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic Acid, a Highly Potent γ-Aminobutyric Acid Aminotransferase Inactivator for the Treatment of Addiction

Jose I. Juncosa, Kenji Takaya, Hoang V. Le et al. · Journal of the American Chemical Society · 2018 · 67 citations

Extensive Rigid Analogue Design Maps the Binding Conformation of Potent <i>N</i>-Benzylphenethylamine 5-HT_2A Serotonin Receptor Agonist Ligands

Jose I. Juncosa, Martin Hansen, Lisa A. Bonner et al. · ACS Chemical Neuroscience · 2012 · 56 citations · Full text

Combinatorial Chemistry, Drug Target, Optimal Binding Conformation +17

PLP and GABA trigger GabR-mediated transcription regulation in <i>Bacillus subtilis</i> via external aldimine formation

Rui Wu, Ruslan Sanishvili, Boris R. Belitsky et al. · Proceedings of the National Academy of Sciences · 2017 · 32 citations · Full text

Mechanism of Inactivation of γ-Aminobutyric Acid Aminotransferase by (1<i>S</i>,3<i>S</i>)-3-Amino-4-difluoromethylene-1-cyclopentanoic Acid (CPP-115)

Hyunbeom Lee, Emma H. Doud, Rui Wu et al. · Journal of the American Chemical Society · 2015 · 30 citations · Full text

γ-Aminobutyric Acid Aminotransferase, Bioorganic Chemistry, Synaptic Transmission +30

Probing the Steric Space at the Floor of the D₁ Dopamine Receptor Orthosteric Binding Domain: 7α-, 7β-, 8α-, and 8β-Methyl Substituted Dihydrexidine Analogues

Juan Pablo Cueva, Alejandra Gallardo‐Godoy, Jose I. Juncosa et al. · Journal of Medicinal Chemistry · 2011 · 18 citations · Full text

Engineering, Organic Chemistry, Small Molecules +17