An aquaporin-4/transient receptor potential vanilloid 4 (AQP4/TRPV4) complex is essential for cell-volume control in astrocytes

Valentina Benfenati, Marco Caprini, Melania Dovizio, +4

Proceedings of the National Academy of Sciences

Aspirin prevents colorectal cancer metastasis in mice by splitting the crosstalk between platelets and tumor cells

Paloma Guillem‐Llobat, Melania Dovizio, Annalisa Bruno, +12

Oncotarget

Tumor BiologyAnti-inflammatoryChemoprevention StrategyMedicinePharmacology +13

Pharmacological Inhibition of Platelet-Tumor Cell Cross-Talk Prevents Platelet-Induced Overexpression of Cyclooxygenase-2 in HT29 Human Colon Carcinoma Cells

Melania Dovizio, Thorsten J. Maier, Sara Alberti, +8

Molecular Pharmacology

Reappraisal of the clinical pharmacology of low‐dose aspirin by comparing novel direct and traditional indirect biomarkers of drug action

Paola Patrignani, Stefania Tacconelli, Elena Piazuelo, +9

Journal of Thrombosis and Haemostasis

Pharmacological StudyMedicineLow‐dose AspirinTraditional Indirect BiomarkersClinical Pharmacology +6

Synthesis, Pharmacological Characterization, and Docking Analysis of a Novel Family of Diarylisoxazoles as Highly Selective Cyclooxygenase-1 (COX-1) Inhibitors

Paola Vitale, Stefania Tacconelli, Maria Grazia Perrone, +8

Journal of Medicinal Chemistry

Pharmacological CharacterizationPharmacotherapyNew SeriesPlatelet AggregationNovel Family +14

Mechanistic and Pharmacological Issues of Aspirin as an Anticancer Agent

Melania Dovizio, Stefania Tacconelli, Carlos Sostres, +2

Pharmaceuticals

Chemoprevention StrategyPharmacotherapyCardiovascular ToxicityAnticancer AgentInflammation +15

Induction of Prostacyclin by Steady Laminar Shear Stress Suppresses Tumor Necrosis Factor-α Biosynthesis via Heme Oxygenase-1 in Human Endothelial Cells

Luigia Di Francesco, Licia Totani, Melania Dovizio, +8

Circulation Research

InflammationAngiogenesisAtherosclerosisMedicineImmunology +13

Carbenoxolone inhibits volume-regulated anion conductance in cultured rat cortical astroglia

Valentina Benfenati, Marco Caprini, Grazia Paola Nicchia, +5

Channels

Platelet-Derived Microparticles From Obese Individuals: Characterization of Number, Size, Proteomics, and Crosstalk With Cancer and Endothelial Cells

Rosalia Grande, Melania Dovizio, Simone Marcone, +11

Frontiers in Pharmacology

Effects of AF3442 [N-(9-ethyl-9H-carbazol-3-yl)-2-(trifluoromethyl)benzamide], a novel inhibitor of human microsomal prostaglandin E synthase-1, on prostanoid biosynthesis in human monocytes in vitro

Annalisa Bruno, Luigia Di Francesco, Isabella Coletta, +11

Biochemical Pharmacology

Medicinal ChemistryNovel InhibitorHuman MonocytesBiochemistryMedicine +8