Deep eutectic solvents and their applications as green solvents

Filippo Maria Perna, Paola Vitale, Vito Capriati

Current Opinion in Green and Sustainable Chemistry

Solvent ExtractionChemical EngineeringEngineeringGreen ChemistryDeep Eutectic Solvents +3

Unprecedented Nucleophilic Additions of Highly Polar Organometallic Compounds to Imines and Nitriles Using Water as a Non‐Innocent Reaction Medium

Giuseppe Dilauro, Marzia Dell’Aera, Paola Vitale, +2

Angewandte Chemie International Edition

Chemical EngineeringNovel OrganocatalystsEngineeringChemical TransformationProton Transfer +11

Synthesis, Pharmacological Characterization, and Docking Analysis of a Novel Family of Diarylisoxazoles as Highly Selective Cyclooxygenase-1 (COX-1) Inhibitors

Paola Vitale, Stefania Tacconelli, Maria Grazia Perrone, +8

Journal of Medicinal Chemistry

Pharmacological CharacterizationPharmacotherapyNew SeriesPlatelet AggregationNovel Family +14

Structural basis for selective inhibition of Cyclooxygenase-1 (COX-1) by diarylisoxazoles mofezolac and 3-(5-chlorofuran-2-yl)-5-methyl-4-phenylisoxazole (P6)

Gino Cingolani, Andrea Panella, Maria Grazia Perrone, +7

European Journal of Medicinal Chemistry

Selective InhibitionMedicinal ChemistryHeterocyclicBiochemistryNatural Sciences +12

Unveiling the Hidden Performance of Whole Cells in the Asymmetric Bioreduction of Aryl‐containing Ketones in Aqueous Deep Eutectic Solvents

Paola Vitale, Vincenzo Mirco Abbinante, Filippo Maria Perna, +3

Advanced Synthesis & Catalysis

EngineeringDeep Eutectic SolventsOrganic ChemistryWhole CellsEnzymatic Modification +14

Novel Synthesis of 3,4-Diarylisoxazole Analogues of Valdecoxib:  Reversal Cyclooxygenase-2 Selectivity by Sulfonamide Group Removal

Leonardo Di Nunno, Paola Vitale, Antonio Scilimati, +2

Journal of Medicinal Chemistry

Ligand‐Free Bioinspired Suzuki–Miyaura Coupling Reactions using Aryltrifluoroborates as Effective Partners in Deep Eutectic Solvents

Giuseppe Dilauro, Sergio Mata García, Tagarelli Donato, +3

ChemSusChem

Water and Sodium Chloride: Essential Ingredients for Robust and Fast Pd‐Catalysed Cross‐Coupling Reactions between Organolithium Reagents and (Hetero)aryl Halides

Giuseppe Dilauro, Andrea Francesca Quivelli, Paola Vitale, +2

Angewandte Chemie International Edition

Sodium ChlorideRoom TemperatureChemical EngineeringCross-coupling ReactionEngineering +12

Sustainable Ligand‐Free Heterogeneous Palladium‐Catalyzed Sonogashira Cross‐Coupling Reaction in Deep Eutectic Solvents

Francesco Messa, Giuseppe Dilauro, Filippo Maria Perna, +3

ChemCatChem

External LigandsChemical EngineeringCross-coupling ReactionEngineeringSonogashira Couplings +8

Novel selective COX-1 inhibitors suppress neuroinflammatory mediators in LPS-stimulated N13 microglial cells

Rosa Calvello, Maria Antonietta Panaro, Maria Luigia Carbone, +5

Pharmacological Research

InflammationAnti-inflammatoryMedicineImmunologyCell Death +8