Crystal structure of the complex between programmed death-1 (PD-1) and its ligand PD-L2

Eszter Lázár‐Molnár, Qingrong Yan, Erhu Cao, +3

Proceedings of the National Academy of Sciences

Crystal StructureDrug TargetMurine Pd-1Cell DeathMolecular Biology +18

Structural basis for cancer immunotherapy by the first-in-class checkpoint inhibitor ipilimumab

U.A. Ramagopal, Weifeng Liu, Sarah C. Garrett-Thomson, +10

Proceedings of the National Academy of Sciences

Human Immune SystemImmunologyImmunoeditingImmunotherapeuticsImmunotherapy +20

Phosphotyrosine-mediated LAT assembly on membranes drives kinetic bifurcation in recruitment dynamics of the Ras activator SOS

William Y. C. Huang, Qingrong Yan, Wan‐Chen Lin, +6

Proceedings of the National Academy of Sciences

Structural Basis for Activation of ZAP-70 by Phosphorylation of the SH2-Kinase Linker

Qingrong Yan, Tiago Barros, Patrick R. Visperas, +4

Molecular and Cellular Biology

Crystal StructureMolecular RegulationMolecular BiologySignaling PathwayReceptor Tyrosine Kinase +16

An electrostatic selection mechanism controls sequential kinase signaling downstream of the T cell receptor

Neel H. Shah, Qi Wang, Qingrong Yan, +7

eLife

T-regulatory CellImmunologyMolecular BiologyPeptide SubstratesCellular Physiology +20

Understanding the Impact of Methionine Oxidation on the Biological Functions of IgG1 Antibodies Using Hydrogen/Deuterium Exchange Mass Spectrometry

Jingjie Mo, Qingrong Yan, Chi So, +3

Analytical Chemistry

Structure Based Prediction of Asparagine Deamidation Propensity in Monoclonal Antibodies

Qingrong Yan, Maggie Huang, Michael Lewis, +1

mAbs

Immunocytochemical TechniqueImmunologyGlycobiologyImmunotherapyDecision Tree +16

Structure of CD84 provides insight into SLAM family function

Qingrong Yan, V.N. Malashkevich, E.V. Fedorov, +5

Proceedings of the National Academy of Sciences

Slam Family FunctionEngineeringGeometryAdaptive Immune SystemImmunology +25

NTB-A Receptor Crystal Structure: Insights into Homophilic Interactions in the Signaling Lymphocytic Activation Molecule Receptor Family

Erhu Cao, U.A. Ramagopal, E.V. Fedorov, +5

Immunity

Homophilic InteractionsSignal TransductionG Protein-coupled ReceptorFunctional SelectivityImmunology +6

Decoy Strategies: The Structure of TL1A:DcR3 Complex

Chenyang Zhan, Y. Patskovsky, Qingrong Yan, +7

Structure

Structural BioinformaticsProtein X-ray CrystallographyMolecular BiologyStructure ElucidationDecoy Strategies +1