Structural basis for cancer immunotherapy by the first-in-class checkpoint inhibitor ipilimumab

U.A. Ramagopal, Weifeng Liu, Sarah C. Garrett-Thomson, +10

Proceedings of the National Academy of Sciences

Human Immune SystemImmunologyImmunoeditingImmunotherapeuticsImmunotherapy +20

Ran GTPase Regulates Hemocytic Phagocytosis of Shrimp by Interaction with Myosin

Weifeng Liu, Fang Han, Xiaobo Zhang

Journal of Proteome Research

BiologyRan GtpasesCell SignalingVirus InfectionPathogenesis +13

Crystal Structure of the Complex of Human FasL and Its Decoy Receptor DcR3

Weifeng Liu, U.A. Ramagopal, Huiyong Cheng, +5

Structure

Decoy Receptor Dcr3Crystal StructureSignal TransductionBiochemistryNatural Sciences +8

Structural Basis of CD160:HVEM Recognition

Weifeng Liu, Sarah C. Garrett, E.V. Fedorov, +4

Structure

EngineeringStructural BioinformaticsPattern RecognitionSignal RecognitionMolecular Biology +3

Mechanistic Basis for Functional Promiscuity in the TNF and TNF Receptor Superfamilies: Structure of the LIGHT:DcR3 Assembly

Weifeng Liu, Chenyang Zhan, Huiyong Cheng, +4

Structure

Photoreceptor CellSignal TransductionSignaling PathwayG Protein-coupled ReceptorMedicine +10

HVEM structures and mutants reveal distinct functions of binding to LIGHT and BTLA/CD160

Weifeng Liu, Ting-Fang Chou, Sarah C. Garrett-Thomson, +11

The Journal of Experimental Medicine

Mouse Hvem MutantsImmunologyMolecular BiologyImmunologic MechanismAntigen Processing +19

Tumor-expressed immune checkpoint B7x promotes cancer progression and antigen-specific CD8 T cell exhaustion and suppressive innate immune cells

Kim C. Ohaegbulam, Weifeng Liu, Hyungjun Jeon, +2

Oncotarget

Structural delineation and phase-dependent activation of the costimulatory CD27:CD70 complex

Weifeng Liu, Zachary Maben, Carole Wang, +13

Journal of Biological Chemistry

Structural Basis for the Divergence of Substrate Specificity and Biological Function within HAD Phosphatases in Lipopolysaccharide and Sialic Acid Biosynthesis

K.D. Daughtry, Hua Huang, V.N. Malashkevich, +8

Biochemistry

Redesigning HVEM Interface for Selective Binding to LIGHT, BTLA, and CD160

Rojan Shrestha, Sarah C. Garrett-Thomson, Weifeng Liu, +2

Structure

PhotonicsHvem InterfaceEngineeringPhysicsOptical Properties +4