Gain-of-function mutations of PPM1D/Wip1 impair the p53-dependent G1 checkpoint

Petra Kleiblová, Indra A. Shaltiël, Jan Benada, +9

The Journal of Cell Biology

Genome InstabilityP53-dependent G1 CheckpointMedicineSerine/threonine Phosphatase Ppm1d/wip1Cell Death +9

High proportion of recurrent germline mutations in the BRCA1 gene in breast and ovarian cancer patients from the Prague area

Petr Pohlreich, Michal Zikán, J. Stříbrná, +8

Breast Cancer Research

The <i>PALB2</i> Gene Is a Strong Candidate for Clinical Testing in <i>BRCA1</i> - and <i>BRCA2</i> -Negative Hereditary Breast Cancer

Markéta Janatová, Zdeněk Kleibl, J. Stříbrná, +7

Cancer Epidemiology Biomarkers & Prevention

The CHEK2 gene I157T mutation and other alterations in its proximity increase the risk of sporadic colorectal cancer in the Czech population

Zdeněk Kleibl, Ondřej Havránek, I. Hlavatá, +4

European Journal of Cancer

MedicineGeneticsProximity IncreaseColorectal CancerPathology +5

The CHEK2 c.1100delC germline mutation rarely contributes to breast cancer development in the Czech Republic

Zdeněk Kleibl, Jan Novotný, Drahomira Bezdickova, +6

Breast Cancer Research and Treatment

Breast OncologySomatic VariantCancer DevelopmentMedicineGenetics +7

Screening for genomic rearrangements in BRCA1 and BRCA2 genes in Czech high-risk breast/ovarian cancer patients: high proportion of population specific alterations in BRCA1 gene

Ivana Tichá, Zdeněk Kleibl, J. Stříbrná, +5

Breast Cancer Research and Treatment

Brca2 GenesBreast OncologyMedicineGeneticsCancer Genomics +6

Contribution of mutations in ATM to breast cancer development in the Czech population

Petr Pohlreich, Pavel Dundr, Zdeněk Kleibl, +1

Oncology Reports

Analysis of CHEK2 FHA domain in Czech patients with sporadic breast cancer revealed distinct rare genetic alterations

Zdeněk Kleibl, Ondřej Havránek, Jan Novotný, +3

Breast Cancer Research and Treatment

Tumor BiologyBreast OncologyOncologyMedicineChek2 Fha Domain +9

Expression of human BRCA1Δ17–19 alternative splicing variant with a truncated BRCT domain in MCF-7 cells results in impaired assembly of DNA repair complexes and aberrant DNA damage response

Jan Ševčı́k, Martin Falk, Libor Macůrek, +11

Cellular Signalling

ChromatinGenome InstabilityMedicineGeneticsChromosomal Rearrangement +6

Novel somatic mutations in the BRCA1 gene in sporadic breast tumors

Markéta Janatová, Michal Zikán, Pavel Dundr, +2

Human Mutation