Cancer stem cell differentiation: TGFβ1 and versican may trigger molecules for the organization of tumor spheroids

Gülperi Öktem, Ümmü Güven, Rüçhan Uslu, +3

Oncology Reports

Induced growth inhibition, cell cycle arrest and apoptosis in CD133+/CD44+ prostate cancer stem cells by flavopiridol

Burak Cem Soner, Hüseyin Aktuğ, Eda Açıkgöz, +5

International Journal of Molecular Medicine

Chemoprevention StrategyInduced Growth InhibitionProstate CscsApoptosisCell Death +17

Enhanced G2/M Arrest, Caspase Related Apoptosis and Reduced E-Cadherin Dependent Intercellular Adhesion by Trabectedin in Prostate Cancer Stem Cells

Eda Açıkgöz, Ümmü Güven, Fahriye Düzağaç, +4

PLoS ONE

Prostate CscsCell AdhesionCell DeathCell ProliferationCell Cycle +19

Targeting SMYD3 to Sensitize Homologous Recombination-Proficient Tumors to PARP-Mediated Synthetic Lethality

Paola Sanese, Candida Fasano, Giacomo Buscemi, +21

iScience

Characterization of CD133⁺/CD44⁺human prostate cancer stem cells with ATR-FTIR spectroscopy

Günnur Güler, Ümmü Güven, Gülperi Öktem

The Analyst

JAK/STAT pathway interacts with intercellular cell adhesion molecule (ICAM) and vascular cell adhesion molecule (VCAM) while prostate cancer stem cells form tumor spheroids.

Fahriye Düzağaç, Sevinç İnan, Ela Simsek F, +7

PubMed

Discovery of the 4-aminopiperidine-based compound EM127 for the site-specific covalent inhibition of SMYD3

Marco Parenti, Marina Naldi, Elisabetta Manoni, +18

European Journal of Medicinal Chemistry

Combinatorial ChemistryMedicinal ChemistryBiochemistrySite-specific Covalent InhibitionNatural Sciences +8

Ribosome biogenesis mediates antitumor activity of flavopiridol in CD44+/CD24‑ breast cancer stem cells

Ayşe Erol, Eda Açıkgöz, Ümmü Güven, +4

Oncology Letters

WNT1 gene expression alters in heterogeneous population of prostate cancer cells; decreased expression pattern observed in CD133+/CD44+ prostate cancer stem cell spheroids.

Gamze Göksel, Rüçhan Uslu, Hakan Akbulut, +2

PubMed

New Psychoactive Substance 5-MeO-MIPT In vivo Acute Toxicity and Hystotoxicological Study

Yusuf Ali Altuncı, Melike Aydoğdu, Eda Açıkgöz, +5

Balkan Medical Journal