Jon Blunt

Palbociclib Commercial Manufacturing Process Development. Part I: Control of Regioselectivity in a Grignard-Mediated S_NAr Coupling

Shengquan Duan, D.W. Place, Hahdi H. Perfect et al. · Organic Process Research & Development · 2016 · 38 citations

Combinatorial Chemistry, Cross-coupling Reaction, Engineering +10

Synthesis of Filibuvir. Part I. Diastereoselective Preparation of a β-Hydroxy Alkynyl Oxazolidinone and Conversion to a 6,6-Disubstituted 2<i>H</i>-Pyranone

Robert A. Singer, John A. Ragan, Paul Bowles et al. · Organic Process Research & Development · 2013 · 24 citations

Dieckmann Cyclization, β-Hydroxy Alkynyl Oxazolidinone, Biosynthesis +14

Development of a Practical and Efficient Synthesis of CP-945,598-01, a CB₁ Antagonist for the Treatment of Obesity

John A. Ragan, Dennis E. Bourassa, Jon Blunt et al. · Organic Process Research & Development · 2008 · 16 citations

Peptide Science, Pharmacotherapy, Efficient Synthesis +17

Synthesis of Filibuvir. Part II. Second-Generation Synthesis of a 6,6-Disubstituted 2<i>H</i>-Pyranone via Dieckmann Cyclization of a β-Acetoxy Ester

Zhihui Peng, John A. Ragan, Roberto Colon-Cruz et al. · Organic Process Research & Development · 2013 · 10 citations

Dieckmann Cyclization, Enantioselective Synthesis, Improved Sequence +13

Synthesis of Filibuvir. Part III. Development of a Process for the Reductive Coupling of an Aldehyde and a β-Keto-lactone

Nathan D. Ide, John A. Ragan, Gabriel Bellavance et al. · Organic Process Research & Development · 2013 · 10 citations

Structural Features, Medicinal Chemistry, Cross-coupling Reaction +14