Genetic deficiency of indoleamine 2,3-dioxygenase promotes gut microbiota-mediated metabolic health

Ludivine Laurans, Nicolas Venteclef, Yacine Haddad, +24

Nature Medicine

ProbioticSystems BiologyDysbiosisMicrobiotaGut Microbiology +8

Parkinsonism-associated Protein DJ-1/Park7 Is a Major Protein Deglycase That Repairs Methylglyoxal- and Glyoxal-glycated Cysteine, Arginine, and Lysine Residues

Gilbert Richarme, Mouadh Mihoub, Julien Dairou, +3

Journal of Biological Chemistry

Guanine glycation repair by DJ-1/Park7 and its bacterial homologs

Gilbert Richarme, Cailing Liu, Mouadh Mihoub, +9

Science

Genome InstabilityDna DamageBiochemistryNatural SciencesGlycobiology +10

Hypothalamic AgRP‐neurons control peripheral substrate utilization and nutrient partitioning

Aurélie Joly‐Amado, R Denis, Julien Castel, +12

The EMBO Journal

Discovery and Function of a General Core Hormetic Stress Response in E. coli Induced by Sublethal Concentrations of Antibiotics

Aurélie Mathieu, Sébastien Fleurier, Antoine Frénoy, +5

Cell Reports

E. ColiBiochemistryAntibioticsNatural SciencesVirulence Factor +8

Formation of CO2, H2 and condensed carbon from siderite dissolution in the 200–300°C range and at 50MPa

Vincent Milesi, François Guyot, Fabrice Brunet, +5

Geochimica et Cosmochimica Acta

Carbon SequestrationChemical EngineeringEngineeringCarbonizationSiderite Dissolution +6

DYRK1A inhibition and cognitive rescue in a Down syndrome mouse model are induced by new fluoro-DANDY derivatives

Fernanda Neumann, Stéphanie Gourdain, Christelle Albac, +13

Scientific Reports

Development of DANDYs, New 3,5-Diaryl-7-azaindoles Demonstrating Potent DYRK1A Kinase Inhibitory Activity

Stéphanie Gourdain, Julien Dairou, Clément Denhez, +6

Journal of Medicinal Chemistry

Medicinal ChemistryBioorganic ChemistryBiochemistryDyrkia KinaseNatural Sciences +11

Inhibition of central de novo ceramide synthesis restores insulin signaling in hypothalamus and enhances β-cell function of obese Zucker rats

Mélanie Campana, Lara Bellini, Claude Rouch, +12

Molecular Metabolism

Glutamate Utilization Couples Oxidative Stress Defense and the Tricarboxylic Acid Cycle in Francisella Phagosomal Escape

Elodie Ramond, Gaël Gesbert, Rigard Mélanie, +7

PLoS Pathogens

Microbial PathogensKlebsiella PneumoniaeImmunologyInnate Immune SystemInnate Immunity +18