Structure-based development and preclinical evaluation of the SARS-CoV-2 3C-like protease inhibitor simnotrelvir

Xiangrui Jiang, Haixia Su, Weijuan Shang, +19

Nature Communications

Toxicity of CdTe Quantum Dots on Yeast <i>Saccharomyces Cerevisiae</i>

Xiaole Han, Lu Lai, Fang-Fang Tian, +10

Small

Disruptive variants of <i>CSDE1</i> associate with autism and interfere with neuronal development and synaptic transmission

Hui Guo, Ying Li, Lu Shen, +70

Science Advances

CERT1 mutations perturb human development by disrupting sphingolipid homeostasis

Charlotte Gehin, Museer A. Lone, Winston Lee, +81

Journal of Clinical Investigation

Neurodegenerative DiseasesMolecular PhysiologyDevelopmental BiologyMolecular NeuroscienceSignal Transduction +12

NCKAP1 Disruptive Variants Lead to a Neurodevelopmental Disorder with Core Features of Autism

Hui Guo, Qiumeng Zhang, Rujia Dai, +55

The American Journal of Human Genetics

Neurodevelopmental DisordersDevelopmental BiologySyndromic AutismGeneticsCore Features +8

Synthesis and biological evaluation of hypoxia-activated prodrugs of SN-38

Jin Chen, Qiumeng Zhang, Wei Lü

European Journal of Medicinal Chemistry

Pharmaceutical ChemistryBiochemistryMedicineHypoxia-activated ProdrugsPharmacology +2

Design, synthesis and biological evaluation of the thioether-containing lenalidomide analogs with anti-proliferative activities

Donghuai Xiao, Yujie Wang, Xiaobei Hu, +6

European Journal of Medicinal Chemistry

Thioether-containing Lenalidomide AnalogsMedicinal ChemistryMedicineAnti-proliferative ActivitiesPharmacological Agent +8

Synthesis and biological evaluation of paclitaxel and vorinostat co-prodrugs for overcoming drug resistance in cancer therapy in vitro

Shuangxi Liu, Kaili Zhang, Qiwen Zhu, +5

Bioorganic & Medicinal Chemistry

Cancer TherapyMedicinal ChemistryHealth SciencesPolymer-drug ConjugateMedicine +8

Biallelic loss-of-function variants in NEMF cause central nervous system impairment and axonal polyneuropathy

Ashfaque Ahmed, Meng Wang, Gaber Bergant, +30

Human Genetics

Neurological DisorderNeuroanatomyGeneticsAxonal PolyneuropathyBiallelic Loss-of-function Variants +7

GIGYF1 disruption associates with autism and impaired IGF-1R signaling

Guodong Chen, Bin Yu, Senwei Tan, +31

Journal of Clinical Investigation

Brain DevelopmentGeneticsDisease Gene IdentificationSocial SciencesAutism Spectrum Disorder +15