Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease

Wenhao Dai, Bing Zhang, Xia-Ming Jiang, +24

Science

Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir

Wanchao Yin, Chunyou Mao, Xiaodong Luan, +18

Science

Viral ReplicationEngineeringViral Polymerase StructureViral Polymerase MechanismMolecular Biology +16

Identification of pyrogallol as a warhead in design of covalent inhibitors for the SARS-CoV-2 3CL protease

Haixia Su, Sheng Yao, Wenfeng Zhao, +16

Nature Communications

Discovery of baicalin and baicalein as novel, natural product inhibitors of SARS-CoV-2 3CL protease <i>in vitro</i>

Haixia Su, Sheng Yao, Wenfeng Zhao, +17

Structural Basis for the Inhibition of the RNA-Dependent RNA Polymerase from SARS-CoV-2 by Remdesivir

Wanchao Yin, Chunyou Mao, Xiaodong Luan, +18

Viral ReplicationEngineeringViral Polymerase StructureViral Polymerase MechanismMolecular Biology +17

Bioactive compounds from Huashi Baidu decoction possess both antiviral and anti-inflammatory effects against COVID-19

Haiyu Xu, Shufen Li, Jiayuan Liu, +30

Proceedings of the National Academy of Sciences

Structure-based development and preclinical evaluation of the SARS-CoV-2 3C-like protease inhibitor simnotrelvir

Xiangrui Jiang, Haixia Su, Weijuan Shang, +19

Nature Communications

Design, Synthesis, and Biological Evaluation of Peptidomimetic Aldehydes as Broad-Spectrum Inhibitors against Enterovirus and SARS-CoV-2

Wenhao Dai, Dirk Jochmans, Hang Xie, +15

Journal of Medicinal Chemistry

Exogenous FABP4 interferes with differentiation, promotes lipolysis and inflammation in adipocytes

Huixia Dou, Ting Wang, Haixia Su, +4

Endocrine

InflammationMetabolic SyndromeInsulin SignalingSignal TransductionPhysiology +8

Small-Molecule Thioesters as SARS-CoV-2 Main Protease Inhibitors: Enzyme Inhibition, Structure–Activity Relationships, Antiviral Activity, and X-ray Structure Determination

Thanigaimalai Pillaiyar, Philipp Flury, Nadine Krüger, +18

Journal of Medicinal Chemistry