Endothelial PI3K-C2α, a class II PI3K, has an essential role in angiogenesis and vascular barrier function

Kazuaki Yoshioka, Kotaro Yoshida, Hong Cui, +21

Nature Medicine

Endothelial Cell PathobiologySignal TransductionDevelopmental BiologyAngiogenesisClass Ii Pi3k +9

S1P3-mediated cardiac fibrosis in sphingosine kinase 1 transgenic mice involves reactive oxygen species

Noriko Takuwa, Sei-Ichiro Ohkura, S Takashima, +23

Cardiovascular Research

S1P2, the G Protein–Coupled Receptor for Sphingosine-1-Phosphate, Negatively Regulates Tumor Angiogenesis and Tumor Growth <i>In vivo</i> in Mice

Wa Du, Noriko Takuwa, Kazuaki Yoshioka, +6

Cancer Research

Sphingosine-1-phosphate receptor-2 deficiency leads to inhibition of macrophage proinflammatory activities and atherosclerosis in apoE-deficient mice

Fei Wang, Yasuo Okamoto, Isao Inoki, +14

Journal of Clinical Investigation

Tumor-suppressive sphingosine-1-phosphate receptor-2 counteracting tumor-promoting sphingosine-1-phosphate receptor-1 and sphingosine kinase 1 - Jekyll Hidden behind Hyde.

Noriko Takuwa, Wa Du, Erika Kaneko, +3

PubMed

ImmunologyTumor-promoting Sphingosine-1-phosphate Receptor-1Cancer BiologyCellular PhysiologyTumor Biology +16

Sphingosine-1-phosphate receptor 2 protects against anaphylactic shock through suppression of endothelial nitric oxide synthase in mice

Hong Cui, Yasuo Okamoto, Kazuaki Yoshioka, +6

Journal of Allergy and Clinical Immunology

InflammationAnaphylactic ShockSignal TransductionAllergyCell Signaling +8

Akt1 and Akt3 Exert Opposing Roles in the Regulation of Vascular Tumor Growth

Thuy L. Phung, Wa Du, Qi Xue, +13

Cancer Research

Sustained delivery of sphingosine-1-phosphate using poly(lactic-co-glycolic acid)-based microparticles stimulates Akt/ERK-eNOS mediated angiogenesis and vascular maturation restoring blood flow in ischemic limbs of mice

Xun Qi, Yasuo Okamoto, Tomomi Murakawa, +9

European Journal of Pharmacology

Tissue EngineeringCell-based Drug DeliveryAngiogenesisEngineeringMedicine +10

Vascular tumors have increased p70 S6-kinase activation and are inhibited by topical rapamycin

Wa Du, Damien Gerald, Carole Perruzzi, +7

Laboratory Investigation

Tumor BiologyOncologyAngiogenesisTopical RapamycinMalignant Disease +10

Genetic ablation of diabetes-associated gene Ccdc92 reduces obesity and insulin resistance in mice

Lü Ren, Wa Du, Dan Song, +7

iScience